HMX2_HUMAN
ID HMX2_HUMAN Reviewed; 273 AA.
AC A2RU54; B2RNV5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Homeobox protein HMX2;
DE AltName: Full=Homeobox protein H6 family member 2;
GN Name=HMX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription factor involved in specification of neuronal
CC cell types and which is required for inner ear and hypothalamus
CC development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR EMBL; CH471066; EAW49288.1; -; Genomic_DNA.
DR EMBL; BC132758; AAI32759.1; -; mRNA.
DR EMBL; BC137139; AAI37140.1; -; mRNA.
DR CCDS; CCDS31305.1; -.
DR RefSeq; NP_005510.1; NM_005519.1.
DR RefSeq; XP_005269800.1; XM_005269743.3.
DR AlphaFoldDB; A2RU54; -.
DR SMR; A2RU54; -.
DR BioGRID; 109410; 4.
DR IntAct; A2RU54; 2.
DR STRING; 9606.ENSP00000341108; -.
DR iPTMnet; A2RU54; -.
DR PhosphoSitePlus; A2RU54; -.
DR BioMuta; HMX2; -.
DR MassIVE; A2RU54; -.
DR PaxDb; A2RU54; -.
DR PeptideAtlas; A2RU54; -.
DR PRIDE; A2RU54; -.
DR ProteomicsDB; 500; -.
DR TopDownProteomics; A2RU54; -.
DR Antibodypedia; 32344; 179 antibodies from 27 providers.
DR DNASU; 3167; -.
DR Ensembl; ENST00000339992.4; ENSP00000341108.3; ENSG00000188816.4.
DR GeneID; 3167; -.
DR KEGG; hsa:3167; -.
DR MANE-Select; ENST00000339992.4; ENSP00000341108.3; NM_005519.2; NP_005510.1.
DR UCSC; uc001lhc.1; human.
DR CTD; 3167; -.
DR DisGeNET; 3167; -.
DR GeneCards; HMX2; -.
DR HGNC; HGNC:5018; HMX2.
DR HPA; ENSG00000188816; Group enriched (brain, kidney).
DR MIM; 600647; gene.
DR neXtProt; NX_A2RU54; -.
DR OpenTargets; ENSG00000188816; -.
DR PharmGKB; PA29345; -.
DR VEuPathDB; HostDB:ENSG00000188816; -.
DR eggNOG; KOG0485; Eukaryota.
DR GeneTree; ENSGT00940000160392; -.
DR HOGENOM; CLU_064096_1_0_1; -.
DR InParanoid; A2RU54; -.
DR OMA; CTQHQAH; -.
DR OrthoDB; 1313583at2759; -.
DR PhylomeDB; A2RU54; -.
DR TreeFam; TF320562; -.
DR PathwayCommons; A2RU54; -.
DR SignaLink; A2RU54; -.
DR BioGRID-ORCS; 3167; 11 hits in 1091 CRISPR screens.
DR GenomeRNAi; 3167; -.
DR Pharos; A2RU54; Tbio.
DR PRO; PR:A2RU54; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A2RU54; protein.
DR Bgee; ENSG00000188816; Expressed in tibialis anterior and 18 other tissues.
DR Genevisible; A2RU54; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..273
FT /note="Homeobox protein HMX2"
FT /id="PRO_0000294366"
FT DNA_BIND 149..208
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 273 AA; 29598 MW; 1100C836F8D131F1 CRC64;
MGSKEDAGKG CPAAGGVSSF TIQSILGGGP SEAPREPVGW PARKRSLSVS SEEEEPDDGW
KAPACFCPDQ HGPKEQGPKH HPPIPFPCLG TPKGSGGSGP GGLERTPFLS PSHSDFKEEK
ERLLPAGSPS PGSERPRDGG AERQAGAAKK KTRTVFSRSQ VYQLESTFDM KRYLSSSERA
CLASSLQLTE TQVKTWFQNR RNKWKRQLSA ELEAANMAHA SAQTLVSMPL VFRDSSLLRV
PVPRSLAFPA PLYYPGSNLS ALPLYNLYNK LDY
