HMX3A_ORYLA
ID HMX3A_ORYLA Reviewed; 303 AA.
AC Q90XP0;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Homeobox protein HMX3-A;
DE AltName: Full=Homeobox protein H6 family member 3-A;
DE AltName: Full=Homeobox protein Nkx-5.1.1;
DE AltName: Full=OlNkx-5.1.1;
GN Name=hmx3a; Synonyms=nkx-5.1.1, nkx5-1.1;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11466530; DOI=10.1007/s004270100162;
RA Adamska M., Wolff A., Kreusler M., Wittbrodt J., Braun T., Bober E.;
RT "Five Nkx5 genes show differential expression patterns in anlagen of
RT sensory organs in medaka: insight into the evolution of the gene family.";
RL Dev. Genes Evol. 211:338-349(2001).
CC -!- FUNCTION: Transcription factor involved in specification of neuronal
CC cell types and which is required for inner ear and hypothalamus
CC development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the ear placode and vesicle and in
CC cells forming the vestibulo-acoustic ganglion.
CC -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR EMBL; AF365970; AAL04484.1; -; Genomic_DNA.
DR AlphaFoldDB; Q90XP0; -.
DR SMR; Q90XP0; -.
DR STRING; 8090.ENSORLP00000007015; -.
DR eggNOG; KOG0485; Eukaryota.
DR InParanoid; Q90XP0; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..303
FT /note="Homeobox protein HMX3-A"
FT /id="PRO_0000341385"
FT DNA_BIND 175..234
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 95..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 303 AA; 34206 MW; 59BB5156AE2F4586 CRC64;
MPETTQETCA PAKDSPFFIK NLLNCDSKPS KPRPVLAATK AALEGGFSLS QVGEFNFPRF
ELPAQRFSLP AHYLERTSAW WYPYTLSSGA HLHRTEVTER PGARDSSPTS GTDRDSPDLV
LKTEPDAKED EDDDEHNNNK SSDEIILEES DAEETKKEEL EEWKKRDEDK KPCRKKKTRT
VFSRSQVFQL ESTFDMKRYL SSSERAGLAA SLHLTETQVK IWFQNRRNKW KRQLAAELEA
ANLSHAAAQR IVRVPILYHE NSASEGGAAA ANVPVSQPLL TFPHPSVYYS HPIVTSVPLL
RPV
