ID   HMX3B_ORYLA             Reviewed;         290 AA.
AC   Q90XN9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Homeobox protein HMX3-B;
DE   AltName: Full=Homeobox protein H6 family member 3-B;
DE   AltName: Full=Homeobox protein Nkx-5.1.2;
DE   AltName: Full=OlNkx-5.1.2;
GN   Name=hmx3b; Synonyms=nkx-5.1.2, nkx5-1.2;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11466530; DOI=10.1007/s004270100162;
RA   Adamska M., Wolff A., Kreusler M., Wittbrodt J., Braun T., Bober E.;
RT   "Five Nkx5 genes show differential expression patterns in anlagen of
RT   sensory organs in medaka: insight into the evolution of the gene family.";
RL   Dev. Genes Evol. 211:338-349(2001).
CC   -!- FUNCTION: Transcription factor involved in specification of neuronal
CC       cell types and which is required for inner ear and hypothalamus
CC       development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in the ear placode and vesicle and in
CC       cells forming the vestibulo-acoustic ganglion.
CC   -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR   EMBL; AF365971; AAL04485.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q90XN9; -.
DR   SMR; Q90XN9; -.
DR   STRING; 8090.ENSORLP00000011972; -.
DR   PRIDE; Q90XN9; -.
DR   eggNOG; KOG0485; Eukaryota.
DR   InParanoid; Q90XN9; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..290
FT                   /note="Homeobox protein HMX3-B"
FT                   /id="PRO_0000341386"
FT   DNA_BIND        166..225
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   290 AA;  32606 MW;  C9ABCF2629DFC2EC CRC64;
     MADSDAQETR PPAKDSPFSI KNLLNIEDKP TKPKNGLGSS KGVFESGFFS RLGDLSLPRF
     ELPAQRIGLP AQYLERASAW WYPYALGTHF RTAGAEKVNQ RETSPILDRH TPDPPKSDQE
     SKEESADDEI ALEESDAEEP KKETDQEDDW MRKGEDLESD KKPCRKKKTR TVFSRSQVFQ
     LESTFDIKRY LSSSERAGLA ASLHLTETQV KIWFQNRRNK WKRQLAAELE AANMSHAAAQ
     RIVRVPILYH DSGAPEATGG PGTNSPGGQP LLSFPHHMYY SNAVPLLRPV