ID   HMX3_CHICK              Reviewed;         308 AA.
AC   O57601;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Homeobox protein HMX3;
DE   AltName: Full=Homeobox protein H6 family member 3;
DE   AltName: Full=Homeobox protein Nkx-5.1;
DE            Short=cNkx5-1;
GN   Name=HMX3; Synonyms=NKX-5.1, NKX5-1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Brain;
RX   PubMed=9435285; DOI=10.1242/dev.125.4.645;
RA   Herbrand H., Guthrie S., Hadrys T., Hoffmann S., Arnold H.H.,
RA   Rinkwitz-Brandt S., Bober E.;
RT   "Two regulatory genes, cNkx5-1 and cPax2, show different responses to local
RT   signals during otic placode and vesicle formation in the chick embryo.";
RL   Development 125:645-654(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=9166590; DOI=10.1007/s003359900463;
RA   Jones C.T., Morrice D.R., Paton I.R., Burt D.W.;
RT   "Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome
RT   identify a new conserved segment.";
RL   Mamm. Genome 8:436-440(1997).
RN   [3]
RP   INDUCTION.
RX   PubMed=17227341; DOI=10.1111/j.1440-169x.2007.00900.x;
RA   Yamanishi T., Katsu K., Funahashi J., Yumoto E., Yokouchi Y.;
RT   "Dan is required for normal morphogenesis and patterning in the developing
RT   chick inner ear.";
RL   Dev. Growth Differ. 49:13-26(2007).
CC   -!- FUNCTION: Transcription factor involved in specification of neuronal
CC       cell types and which is required for inner ear and hypothalamus
CC       development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the otic placode beginning at stage
CC       10 and exhibits a dynamic expression pattern during formation and
CC       further differentiation of the otic vesicle.
CC       {ECO:0000269|PubMed:9435285}.
CC   -!- INDUCTION: Regulated by DAN in inner ear.
CC       {ECO:0000269|PubMed:17227341}.
CC   -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR   EMBL; Y15989; CAA75921.1; -; Genomic_DNA.
DR   RefSeq; NP_001007986.1; NM_001007985.1.
DR   AlphaFoldDB; O57601; -.
DR   SMR; O57601; -.
DR   STRING; 9031.ENSGALP00000011796; -.
DR   PaxDb; O57601; -.
DR   GeneID; 429199; -.
DR   KEGG; gga:429199; -.
DR   CTD; 340784; -.
DR   VEuPathDB; HostDB:geneid_429199; -.
DR   eggNOG; KOG0485; Eukaryota.
DR   InParanoid; O57601; -.
DR   OrthoDB; 1313583at2759; -.
DR   PhylomeDB; O57601; -.
DR   PRO; PR:O57601; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..308
FT                   /note="Homeobox protein HMX3"
FT                   /id="PRO_0000341383"
FT   DNA_BIND        181..240
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  33787 MW;  568B77CBF9C4968B CRC64;
     MPETGQEPPS APPPPPPPKE SFYIKNLLNG DPPKAAPKQP RALFAPSGKA DGSGFALSQV
     GDLSFPRFEI PAPRFALSAH CLERAQTWWY PYALTPAGAH LPRTEAAEKS LLRDSSPASG
     TDRDSPEPLL QGGDAEQKER DPKSPAEIVL EESDSEEGKK EGGAEDWKKR EESPEKKPCR
     KKKTRTVFSR SQVFQLESTF DMKRYLSSSE RAGLAASLHL TETQVKIWFQ NRRNKWKRQL
     AAELEAANLS HAAAQRIVRV PILYHENSGA ESSAAGGGGP GPQPLLTFPH PVYYSHPSVT
     SVPLLRPV