HMX3_DANRE
ID HMX3_DANRE Reviewed; 297 AA.
AC Q504H8; A9Y2A8; Q9DFB1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Homeobox protein HMX3;
DE AltName: Full=Homeobox protein H6 family member 3;
DE AltName: Full=Homeobox protein Nkx-5.1;
GN Name=hmx3; Synonyms=nkx-5.1, nkx5-1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11025218; DOI=10.1016/s0925-4773(00)00414-7;
RA Adamska M., Leger S., Brand M., Hadrys T., Braun T., Bober E.;
RT "Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its
RT downregulation in the ears of FGF8 mutant, ace.";
RL Mech. Dev. 97:161-165(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AB;
RA Feng Y., Xu Q.;
RT "Conserved homeobox genes Hmx2 and Hmx3 play a pivotal role in zebrafish
RT inner ear and lateral line development.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INDUCTION.
RX PubMed=12399318; DOI=10.1242/dev.129.22.5279;
RA Kwak S.-J., Phillips B.T., Heck R., Riley B.B.;
RT "An expanded domain of fgf3 expression in the hindbrain of zebrafish
RT valentino mutants results in mis-patterning of the otic vesicle.";
RL Development 129:5279-5287(2002).
CC -!- FUNCTION: Transcription factor involved in specification of neuronal
CC cell types and which is required for inner ear and hypothalamus
CC development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the ear placode and vesicle and in
CC cells forming the vestibulo-acoustic ganglion. Also expressed in the
CC lateral line. {ECO:0000269|PubMed:11025218}.
CC -!- INDUCTION: Regulated by fgf3 and fgf8 in otic vesicle.
CC {ECO:0000269|PubMed:11025218, ECO:0000269|PubMed:12399318}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR EMBL; AF288211; AAG17822.1; -; mRNA.
DR EMBL; EU050651; ABW07818.1; -; mRNA.
DR EMBL; BC095015; AAH95015.1; -; mRNA.
DR AlphaFoldDB; Q504H8; -.
DR SMR; Q504H8; -.
DR STRING; 7955.ENSDARP00000095383; -.
DR PaxDb; Q504H8; -.
DR ZFIN; ZDB-GENE-001020-1; hmx3a.
DR eggNOG; KOG0485; Eukaryota.
DR InParanoid; Q504H8; -.
DR PhylomeDB; Q504H8; -.
DR PRO; PR:Q504H8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:ZFIN.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0048916; P:posterior lateral line development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..297
FT /note="Homeobox protein HMX3"
FT /id="PRO_0000341384"
FT DNA_BIND 170..229
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 35
FT /note="I -> T (in Ref. 2; ABW07818)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="I -> V (in Ref. 1; AAG17822)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="G -> S (in Ref. 1; AAG17822 and 2; ABW07818)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="G -> S (in Ref. 2; ABW07818)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 33088 MW; 4952EA67564235FE CRC64;
MPETTQDTCA SAKDSPFFIK NLLNSDSKPS KPKPILAPTK AGLDGSFSLS QVGEINFPRF
ELPTQRFALP AYLERASAWW YPYTLSASAH LHRTEAAQKA RDSSPTTGTD RDSPELVLKS
DPDAKDDEDD NKSGDEIVLE EGDTEDGKKE GGIDDWKKSD DGADKKPCRK KKTRTVFSRS
QVFQLESTFD MKRYLSSSER AGLAASLHLT ETQVKIWFQN RRNKWKRQLA AELEAANLSH
AAAQRIVRVP ILYHENSASE STNTAGNVPV SQPLLTFPHP VYYSHPIVTS VPLLRPV
