ID   HMX3_XENLA              Reviewed;         306 AA.
AC   Q8JJ64; A9JS82;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Homeobox protein HMX3;
DE   AltName: Full=Homeobox protein H6 family member 3;
DE   AltName: Full=Homeobox protein Nkx-5.1;
DE            Short=X-nkx-5.1;
GN   Name=hmx3; Synonyms=nkx-5.1, nkx5-1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DNA-BINDING, FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=15511636; DOI=10.1016/j.mod.2004.08.002;
RA   Bayramov A.V., Martynova N.Y., Eroshkin F.M., Ermakova G.V., Zaraisky A.G.;
RT   "The homeodomain-containing transcription factor X-nkx-5.1 inhibits
RT   expression of the homeobox gene Xanf-1 during the Xenopus laevis forebrain
RT   development.";
RL   Mech. Dev. 121:1425-1441(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-306.
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor involved in specification of neuronal
CC       cell types and which is required for inner ear and hypothalamus
CC       development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).
CC       May act as a stage-specific inhibitor of anf1 in the anterior neural
CC       plate during the development. {ECO:0000250,
CC       ECO:0000269|PubMed:15511636}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the embryonic brain and in the
CC       ciliated cells of the otic and lateral line placodes. Also expressed in
CC       precursors of the epidermal ciliated cells. Expressed early in the
CC       anterior neural plate starts early. {ECO:0000269|PubMed:15511636}.
CC   -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR   EMBL; AF368235; AAM21210.1; -; mRNA.
DR   EMBL; BC155953; AAI55954.1; -; mRNA.
DR   RefSeq; NP_001079226.1; NM_001085757.1.
DR   AlphaFoldDB; Q8JJ64; -.
DR   SMR; Q8JJ64; -.
DR   GeneID; 373845; -.
DR   KEGG; xla:373845; -.
DR   CTD; 373845; -.
DR   Xenbase; XB-GENE-865014; hmx3.L.
DR   OMA; CAPAKDS; -.
DR   OrthoDB; 1313583at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 373845; Expressed in internal ear and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..306
FT                   /note="Homeobox protein HMX3"
FT                   /id="PRO_0000341387"
FT   DNA_BIND        178..237
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          95..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   306 AA;  34022 MW;  F1876FC66AD35FF4 CRC64;
     MPETGQESSN PPAKESPFSI KSLLTCEPSR AARPPKALFT PIKGALDGAA FAFSPLTDFT
     FPRLEIPTQR FALPAHYLER SPGWWYSYTL AHGGHTPRTE VPDKSLLLGP TSPVSGGERD
     SPDPIHPLKT ELGAKESESK SPEEIILEES DPEEGKKDDS GEDWKKREDS PDKKPCRKKK
     TRTVFSRSQV FQLESTFDMK RYLSSSERAG LAASLHLTET QVKIWFQNRR NKWKRQLAAE
     LEAANLSHAA AQRIVRVPIL YHENSSSAES ASSAANVPVS QPLLTFPHPV YYSHPVVTSV
     PLLRPV