HMX3_XENTR
ID HMX3_XENTR Reviewed; 306 AA.
AC Q0P4W6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Homeobox protein HMX3;
DE AltName: Full=Homeobox protein H6 family member 3;
DE AltName: Full=Homeobox protein Nkx-5.1;
GN Name=hmx3; Synonyms=nkx-5.1, nkx5-1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in specification of neuronal
CC cell types and which is required for inner ear and hypothalamus
CC development. Binds to the 5'-CAAGTG-3' core sequence. May act as a
CC stage-specific inhibitor of anf1 in the anterior neural plate during
CC the development (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR EMBL; BC121874; AAI21875.1; -; mRNA.
DR RefSeq; NP_001072829.1; NM_001079361.1.
DR AlphaFoldDB; Q0P4W6; -.
DR SMR; Q0P4W6; -.
DR PaxDb; Q0P4W6; -.
DR DNASU; 780290; -.
DR Ensembl; ENSXETT00000021090; ENSXETP00000021090; ENSXETG00000009562.
DR GeneID; 780290; -.
DR KEGG; xtr:780290; -.
DR CTD; 340784; -.
DR Xenbase; XB-GENE-483776; hmx3.
DR eggNOG; KOG0485; Eukaryota.
DR HOGENOM; CLU_064096_0_0_1; -.
DR InParanoid; Q0P4W6; -.
DR OMA; GGDKKAC; -.
DR OrthoDB; 1313583at2759; -.
DR PhylomeDB; Q0P4W6; -.
DR TreeFam; TF320562; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000009562; Expressed in neurula embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..306
FT /note="Homeobox protein HMX3"
FT /id="PRO_0000341388"
FT DNA_BIND 178..237
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 95..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 306 AA; 34077 MW; 30D11D67B913BA15 CRC64;
MPETGQESSN PPAKESPFSI KSLLTCEPSR AVRPHKALFT PIKGALDGAA FALSPLTDLT
FPRLEIPAQR FALPAHYLER SPAWWYSYTL AHGGHTPRTE VPDKSLLLGP TSPVSGGERD
SPEPIHPLKA ELEAKDSESK SPEEIILEES EPEEGKKDDS GEDWKKREES PDKKPCRKKK
TRTVFSRSQV FQLESTFDMK RYLSSSERAG LAASLHLTET QVKIWFQNRR NKWKRQLAAE
LEAANLSHAA AQRIVRVPIL YHENSSSAES ASSAANVPVS QPLLTFPHPV YYSHPVVTSV
PLLRPV
