ID   HMX_STRPU               Reviewed;         405 AA.
AC   Q26656;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Homeobox protein Hmx;
DE            Short=SpHmx;
DE   AltName: Full=H6-like;
DE   Flags: Fragment;
GN   Name=HMX;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=9013931; DOI=10.1006/dbio.1996.8461;
RA   Martinez P., Davidson E.H.;
RT   "SpHmx, a sea urchin homeobox gene expressed in embryonic pigment cells.";
RL   Dev. Biol. 181:213-222(1997).
CC   -!- FUNCTION: May be a cell-type-specific regulator of pigment cell
CC       differentiation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Developing pigment cells. Also maternally expressed
CC       in oocytes.
CC   -!- DEVELOPMENTAL STAGE: Expressed in mid-gastrula stages throughout the
CC       archenteron and in delaminating secondary mesenchyme cells. At later
CC       stages (prism and pluteus) expression is seen exclusively in pigment
CC       cells.
CC   -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR   EMBL; D85079; BAA12721.1; -; mRNA.
DR   RefSeq; NP_999726.1; NM_214561.2.
DR   AlphaFoldDB; Q26656; -.
DR   SMR; Q26656; -.
DR   EnsemblMetazoa; NM_214561; NP_999726; GeneID_373358.
DR   GeneID; 373358; -.
DR   KEGG; spu:373358; -.
DR   CTD; 42110; -.
DR   HOGENOM; CLU_1543934_0_0_1; -.
DR   InParanoid; Q26656; -.
DR   OMA; WGRNGIG; -.
DR   OrthoDB; 1313583at2759; -.
DR   PhylomeDB; Q26656; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..>405
FT                   /note="Homeobox protein Hmx"
FT                   /id="PRO_0000048980"
FT   DNA_BIND        253..312
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         405
SQ   SEQUENCE   405 AA;  44739 MW;  8D3739DC9A5CF261 CRC64;
     MDSSRELSGE EPRSPSPRHE TSKMRLSPDR PSHHPARPPA SLASQPLRPA HYQDDDDSYR
     THTPPPSQPR TKGFSIESIL SPTDKHRKSP RSPPMSPSSP SMSSNGYSEG PIYGSTRHPL
     SATVPGLGRA ALDELAAHRA AALHIPSAAL PFSHLAHNPA FYAWMHGASF LHYHGMPAFN
     SHPPIAQPLT NSSRLAMAKD ISPRPTQSHS SFGEEGGEKD SRGRESPDSE HRRNNGHEED
     DDDDDDQSPQ KKKKKTRTVF SRSQVFQLES TFEVKRYLSS SERAGLAANL HLTETQVKIW
     FQNRRNKWKR QMAAELESAN LAHAAQIRAQ ANLAQVSAVH VHAYAQRMVR VPILYHENHP
     TTGSSLHSPN ILPFPMPYPG SYHQISSSTS STSSARSPTS TSIVT