HN1BA_DANRE
ID HN1BA_DANRE Reviewed; 559 AA.
AC A1L1N5; Q6EEZ4; Q8UW01; Q90X59;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Hepatocyte nuclear factor 1-beta-A;
DE Short=HNF-1-beta-A;
DE Short=HNF-1B-A;
DE AltName: Full=Hepatocyte nuclear factor 1-beta-2;
DE Short=HNF-1B-2;
DE AltName: Full=Transcription factor 2;
DE Short=TCF-2;
DE AltName: Full=Variant hepatic nuclear factor 1;
DE Short=vHNF1;
GN Name=hnf1ba; Synonyms=hnf1b, tcf2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=15302404; DOI=10.1016/j.gene.2004.05.003;
RA Gong H.-Y., Lin C.J.-F., Chen M.H.-C., Hu M.-C., Lin G.-H., Zhou Y.,
RA Zon L.I., Wu J.-L.;
RT "Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and
RT hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of
RT zebrafish.";
RL Gene 338:35-46(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11731484; DOI=10.1101/gad946701;
RA Sun Z., Hopkins N.;
RT "vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional
RT specification of the zebrafish gut, pronephros, and hindbrain.";
RL Genes Dev. 15:3217-3229(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=18945197; DOI=10.1089/zeb.2008.0534;
RA Choe S.-K., Hirsch N., Zhang X., Sagerstrom C.G.;
RT "hnf1b genes in zebrafish hindbrain development.";
RL Zebrafish 5:179-187(2008).
CC -!- FUNCTION: Transcription factor that binds to the inverted palindrome
CC 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of
CC rhombomere r5/r6 gene expression in the hindbrain.
CC {ECO:0000250|UniProtKB:P35680, ECO:0000269|PubMed:18945197}.
CC -!- SUBUNIT: Binds DNA as a dimer. Can form homodimer or heterodimer with
CC HNF1-alpha (By similarity). {ECO:0000250|UniProtKB:P35680}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: During embryonic development, expressed dynamically
CC in the developing hindbrain, kidney (pronephros), gut, liver and
CC pancreas; expressed in both intermediate mesoderm (precursor to the
CC kidney) and the caudal hindbrain (including rhombomeres r5 and r6) at
CC 10 hpf with expression diminishing caudally by 14 hpf. Strongly
CC expressed in adult kidney, gut, liver and swim bladder; weakly
CC expressed in brain, eye, testis, ovary and heart.
CC {ECO:0000269|PubMed:15302404, ECO:0000269|PubMed:18945197}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Significantly expressed after the onset of gastrulation and throughout
CC embryonic development. {ECO:0000269|PubMed:11731484,
CC ECO:0000269|PubMed:15302404}.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL30666.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF244140; AAL48193.2; -; mRNA.
DR EMBL; AY336602; AAR02405.1; -; mRNA.
DR EMBL; AF430840; AAL30666.1; ALT_INIT; mRNA.
DR EMBL; BC129147; AAI29148.1; -; mRNA.
DR RefSeq; NP_571955.3; NM_131880.3.
DR AlphaFoldDB; A1L1N5; -.
DR BMRB; A1L1N5; -.
DR SMR; A1L1N5; -.
DR BioGRID; 657079; 1.
DR STRING; 7955.ENSDARP00000119593; -.
DR PaxDb; A1L1N5; -.
DR PeptideAtlas; A1L1N5; -.
DR GeneID; 792391; -.
DR KEGG; dre:792391; -.
DR CTD; 792391; -.
DR ZFIN; ZDB-GENE-020104-1; hnf1ba.
DR eggNOG; ENOG502QRPW; Eukaryota.
DR InParanoid; A1L1N5; -.
DR OrthoDB; 409935at2759; -.
DR PhylomeDB; A1L1N5; -.
DR TreeFam; TF320327; -.
DR PRO; PR:A1L1N5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:ZFIN.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; ISS:ZFIN.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:ZFIN.
DR GO; GO:0034672; P:anterior/posterior pattern specification involved in pronephros development; IGI:ZFIN.
DR GO; GO:0048546; P:digestive tract morphogenesis; IMP:ZFIN.
DR GO; GO:0048566; P:embryonic digestive tract development; IMP:ZFIN.
DR GO; GO:0031018; P:endocrine pancreas development; IMP:ZFIN.
DR GO; GO:0001706; P:endoderm formation; IDA:MGI.
DR GO; GO:0042593; P:glucose homeostasis; IMP:ZFIN.
DR GO; GO:0061008; P:hepaticobiliary system development; IGI:ZFIN.
DR GO; GO:0030902; P:hindbrain development; IMP:UniProtKB.
DR GO; GO:0021575; P:hindbrain morphogenesis; IMP:ZFIN.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0035622; P:intrahepatic bile duct development; IGI:ZFIN.
DR GO; GO:0001889; P:liver development; IMP:ZFIN.
DR GO; GO:0072576; P:liver morphogenesis; IMP:ZFIN.
DR GO; GO:0043049; P:otic placode formation; IMP:ZFIN.
DR GO; GO:0030916; P:otic vesicle formation; IMP:ZFIN.
DR GO; GO:0048840; P:otolith development; IGI:ZFIN.
DR GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR GO; GO:0031016; P:pancreas development; IMP:ZFIN.
DR GO; GO:1990798; P:pancreas regeneration; IMP:ZFIN.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021571; P:rhombomere 5 development; IMP:ZFIN.
DR GO; GO:0021664; P:rhombomere 5 morphogenesis; IMP:ZFIN.
DR GO; GO:0021572; P:rhombomere 6 development; IMP:ZFIN.
DR GO; GO:0021667; P:rhombomere 6 morphogenesis; IMP:ZFIN.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IMP:ZFIN.
DR GO; GO:0035148; P:tube formation; IMP:ZFIN.
DR GO; GO:0003323; P:type B pancreatic cell development; IMP:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; PTHR11568; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF100957; SSF100957; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..559
FT /note="Hepatocyte nuclear factor 1-beta-A"
FT /id="PRO_0000343423"
FT DOMAIN 5..36
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 100..195
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 240..320
FT /note="Homeobox; HNF1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..35
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT REGION 53..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 370
FT /note="T -> S (in Ref. 3; AAI29148)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 559 AA; 61339 MW; 8356746E724D3C26 CRC64;
MFANMVSKLT SLQQELLSAL LDSGVTKDVL LQALEDLDPS PSAFGVKLDS LQMSPSGSKL
SDTDSKPVFH TLTNGHSKGK LSGDEGSEDG DDYDTPPILK ELQSQNTEEA AEQRAEIERM
LAEDPWRAAR MIKGYMQQHN IPQREVVDVT GLNQSHLSQH LNKGTPMKTQ KRAALYTWYV
RKQREILRQF NQATQGSGAT MLDKGNQDQV LLFFSEFSQS GQGMVQPGDD AAIEPACKKL
RRNRFKWGPA SQQILYQAYE RQKNPSKEER EALVEECNRA ECLQRGVSPS KAHGLGSNLV
TEVRVYNWFA NRRKEEAFRQ KLAMDAYSGP AHSLNSLLSH SSPHHPQTSS SPPSKMQGVR
YSQQGPGEVT SSTTINHHSS NAMSTSQSVL QQVSPGALDP SHSLLSPDAK MISVSGGGLP
PVSTLTNIHA SHHVHQQTPN LIMPLSGVMA IAQSLNTSQA QTVPVINSVA GSLAALQPVQ
FSQQLNSQHQ QLMQQSSGHM SQQSFMASVS HSHMYPHKQE PPQYSHSSRF PPAMVVTDAN
SLSTLSSMSS SKQCPLQAW
