HN1BB_DANRE
ID HN1BB_DANRE Reviewed; 532 AA.
AC Q8UW00;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Hepatocyte nuclear factor 1-beta-B {ECO:0000250|UniProtKB:P35680};
DE Short=HNF-1-beta-B {ECO:0000250|UniProtKB:P35680};
DE Short=HNF-1B-B {ECO:0000250|UniProtKB:P35680};
DE AltName: Full=Hepatocyte nuclear factor 1-beta-like {ECO:0000303|PubMed:18945197};
DE AltName: Full=Hepatocyte nuclear factor 1-gamma {ECO:0000303|Ref.1};
DE Short=HNF1g {ECO:0000303|Ref.1};
GN Name=hnf1bb {ECO:0000312|ZFIN:ZDB-GENE-030131-3003};
GN Synonyms=hnf1bl {ECO:0000303|PubMed:18945197}, hnf1g {ECO:0000303|Ref.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAL48194.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL48194.1};
RA Gong H.-Y., Hu M.-C., Lin C.J.-F., Chen M.C., Chen M.H.-C., Weng C.F.,
RA Wu J.-L.;
RT "Developmental expression of HNF1g, a novel hepatocyte nuclear factor 1,
RT and HNF1b homolog in zebrafish pronephros formation.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=18945197; DOI=10.1089/zeb.2008.0534;
RA Choe S.-K., Hirsch N., Zhang X., Sagerstrom C.G.;
RT "hnf1b genes in zebrafish hindbrain development.";
RL Zebrafish 5:179-187(2008).
CC -!- FUNCTION: Transcription factor that binds to the inverted palindrome
CC 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is
CC not required for induction of rhombomere r5/r6 gene expression in the
CC hindbrain. {ECO:0000250|UniProtKB:P35680, ECO:0000269|PubMed:18945197}.
CC -!- SUBUNIT: Binds DNA as a dimer. Can form homodimer or heterodimer with
CC HNF1-alpha (By similarity). {ECO:0000250|UniProtKB:P35680}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35680,
CC ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: First expressed at stage 10 in the intermediate
CC mesoderm. Expressed in rhombomere r5 by 14 hpf with expression
CC diminishing by 18 hpf. {ECO:0000269|PubMed:18945197}.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000255}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF250352; AAL48194.1; -; mRNA.
DR RefSeq; NP_919353.1; NM_194372.2.
DR AlphaFoldDB; Q8UW00; -.
DR SMR; Q8UW00; -.
DR STRING; 7955.ENSDARP00000038789; -.
DR PaxDb; Q8UW00; -.
DR Ensembl; ENSDART00000177616; ENSDARP00000143259; ENSDARG00000022295.
DR GeneID; 324283; -.
DR KEGG; dre:324283; -.
DR CTD; 324283; -.
DR ZFIN; ZDB-GENE-030131-3003; hnf1bb.
DR eggNOG; ENOG502QRPW; Eukaryota.
DR GeneTree; ENSGT00940000153818; -.
DR InParanoid; Q8UW00; -.
DR OrthoDB; 409935at2759; -.
DR PhylomeDB; Q8UW00; -.
DR PRO; PR:Q8UW00; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 21.
DR Bgee; ENSDARG00000022295; Expressed in mesonephros and 24 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034672; P:anterior/posterior pattern specification involved in pronephros development; IGI:ZFIN.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; PTHR11568; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF100957; SSF100957; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..532
FT /note="Hepatocyte nuclear factor 1-beta-B"
FT /id="PRO_0000389524"
FT DOMAIN 5..36
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 102..197
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 244..324
FT /note="Homeobox; HNF1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..35
FT /note="Dimerization"
FT /evidence="ECO:0000250|UniProtKB:P15257"
FT REGION 74..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 58320 MW; 88045D5D6510A799 CRC64;
MFTDMVSKLT SLQQELLSAL LDSGVTKDVL VQALEDLCPC PAEFGIKIEK PLSPSSANGG
SDCGDSKPVF LTLTGAQGKG GKLSGDEGSE DGDDFDTPPI LRELQSLNTE EAAEQRAEVD
RMLSEDPWRV ARTIKGYMQQ HNIPQREVVD VTGLNQSHLS QHLNKGTPMK TAKRAALYTW
YVQKQREIDR QFDRVQGSDP SDSASQDQVL FFFPEFNHGG HSSGAAGGSG AAVGDEGEPG
SKRMRRNRFK WGPASQEILY QAYERQKNPS KEEREALVEE CNRAECVQRG VSPSKAHGLG
SNLVTEVRVY NWFANRRKEE AFRQKLAMDT YTPHMNPLLS HTASLSHHHS SESKLRYSQQ
AASEVTSSTT ISHPSVLQQV SPGGLDHCHG LLSTDAKMIS VSGGVLPPVS TLTNIHSLSQ
SSHHHHHHHH QQAQSLIMSL AAQSLTSPQS QSVPVINSVS GLTTLQPMQF PQSSSLTQLT
TAHISQQPFA QSHMYSPKQE AGQFSHPSRY STMDSSTITH LGSSKQCPLQ AW
