ID   HN423_CYRHA             Reviewed;          32 AA.
AC   P0CH72;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=U3-theraphotoxin-Hhn1r;
DE            Short=U3-TRTX-Hhn1r;
DE   AltName: Full=Hainantoxin F4-23.43;
DE   AltName: Full=Peptide F4-23.43;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- FUNCTION: Ion channel inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 16 (Hntx-8)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH72; -.
DR   SMR; P0CH72; -.
DR   ArachnoServer; AS001810; U3-theraphotoxin-Hhn1r.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   InterPro; IPR013140; Huwentoxin_CS1.
DR   Pfam; PF07740; Toxin_12; 1.
DR   PROSITE; PS60021; HWTX_1; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Secreted; Toxin.
FT   PEPTIDE         1..32
FT                   /note="U3-theraphotoxin-Hhn1r"
FT                   /id="PRO_0000400720"
FT   DISULFID        2..15
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        14..27
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   32 AA;  3673 MW;  61A5F75A74A107D2 CRC64;
     DCAGYMRECK EKLCCSGYVC SSRWKWCVLP AP