ID   HN522_CYRHA             Reviewed;          43 AA.
AC   P0CH73;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Hainantoxin F5-22.36;
DE   AltName: Full=Peptide F5-22.36;
DE   Flags: Fragment;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- FUNCTION: Probable ion channel inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20192277}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:20192277}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 02 (HWTX-
CC       XVIc) subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH73; -.
DR   SMR; P0CH73; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012627; Toxin_22.
DR   Pfam; PF08092; Toxin_22; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Secreted; Toxin.
FT   PEPTIDE         1..>43
FT                   /note="Hainantoxin F5-22.36"
FT                   /id="PRO_0000400967"
FT   DISULFID        1..19
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        18..38
FT                   /evidence="ECO:0000250"
FT   NON_TER         43
SQ   SEQUENCE   43 AA;  5061 MW;  A1482BE015FC5D66 CRC64;
     CNGRDVPCDP DPAKNRRCCS GLECLKPYLH GTWYQDYCYY VEK