HNF1A_CHICK
ID HNF1A_CHICK Reviewed; 634 AA.
AC Q90867;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Hepatocyte nuclear factor 1-alpha;
DE Short=HNF-1-alpha;
DE Short=HNF-1A;
DE AltName: Full=Transcription factor 1;
DE Short=TCF-1;
GN Name=HNF1A; Synonyms=TCF1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=White leghorn;
RX PubMed=8105803; DOI=10.1515/bchm3.1993.374.7-12.419;
RA Hoerlein A., Grajer K.-H., Igo-Kemenes T.;
RT "Genomic structure of the POU-related hepatic transcription factor HNF-1
RT alpha.";
RL Biol. Chem. Hoppe-Seyler 374:419-425(1993).
RN [2]
RP FUNCTION.
RX PubMed=7687846; DOI=10.1515/bchm3.1993.374.1-6.319;
RA Grajer K.-H., Hoerlein A., Igo-Kemenes T.;
RT "Hepatic nuclear factor 1 alpha (HNF-1 alpha) is expressed in the oviduct
RT of hens and interacts with regulatory elements of the lysozyme gene.";
RL Biol. Chem. Hoppe-Seyler 374:319-326(1993).
CC -!- FUNCTION: Transcriptional activator that regulates the tissue specific
CC expression of multiple genes, especially in pancreatic islet cells and
CC in liver. May participate in the control of the hormone-dependent
CC expression of the lysozyme gene in the oviduct and liver. In liver it
CC could repress the gene while in oviduct it may act as an activator.
CC {ECO:0000269|PubMed:7687846}.
CC -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in liver and in oviduct.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
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DR EMBL; X67689; CAA47920.1; -; Genomic_DNA.
DR EMBL; X67690; CAA47920.1; JOINED; Genomic_DNA.
DR PIR; S35574; S35574.
DR AlphaFoldDB; Q90867; -.
DR SMR; Q90867; -.
DR STRING; 9031.ENSGALP00000037563; -.
DR PaxDb; Q90867; -.
DR VEuPathDB; HostDB:geneid_416967; -.
DR eggNOG; ENOG502QRPW; Eukaryota.
DR InParanoid; Q90867; -.
DR PhylomeDB; Q90867; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR InterPro; IPR006898; HNF1a_C.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; PTHR11568; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04813; HNF-1A_C; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF100957; SSF100957; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..634
FT /note="Hepatocyte nuclear factor 1-alpha"
FT /id="PRO_0000049118"
FT DOMAIN 1..32
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 90..185
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 202..282
FT /note="Homeobox; HNF1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT REGION 50..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..135
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 146..152
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 158..161
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 206..209
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 266..268
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 273..276
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 287..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 200..208
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 289..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 69189 MW; A1CA1C4A15410919 CRC64;
MVSKLSHLQV ELLGALLESG LTKETLIKGL SEAEPYVLQS ESQHAINALQ TEKGESCPEI
PNLPNGMGET RLSEDETSDD GEEFTPPIMK ELENLSPEEA AHQKAVVERL LQEDPWRVAK
MVKSYLQQHN IPQREVVDTT GLNQSHLSQH LNKGTPMKTQ KRAALYTWYV RKQREVAQQF
THAGQGILTE EPMGDDLPTK KGRRNRFKWG PASQQILFQA YERQKNPSKE EREALVEECN
RAECIQRGVS PSQAQGLGSN LVTEVRVYNW FANRRKEEAF RHKLAMDNFS GPQPTSAPPL
TPHNSSSLQP PPALSPTKVH GVRYNQQPAS EAESSSSNHH GNSSMVTTQT ILHQVSPPGL
EPSQNLLSTD TKLISAPGGT LPPVSTLTAL HSLEQNPHAL GQQTQNLIMA SLPGVMAIGA
GETSSLAPRF TNTGGSTLVI GLTSTQPQSV PVINSMGSSL TTLQPVQFSQ QLHPSYQQPL
MQQVQSHINQ SPFMATMAQI QNPHALYGPK SEVAQYTHTG LLPQTMVITD TANLSALTNL
TPTKQAFTSD SETHTDSGIH TPVSQAPAIH LQNQDTAIQH LQSGPRLTPS PAVSSSSLVL
YQSSDSTNSH SQLLPSTHNV IETFISTQMA SSTQ
