HNF1A_SALSA
ID HNF1A_SALSA Reviewed; 559 AA.
AC Q91474;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Hepatocyte nuclear factor 1-alpha;
DE Short=HNF-1-alpha;
DE Short=HNF-1A;
DE AltName: Full=Transcription factor 1;
DE Short=TCF-1;
DE AltName: Full=sHNF1;
GN Name=hnf1a; Synonyms=hnf1, tcf1;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=7897653; DOI=10.1006/jmbi.1994.0115;
RA Deryckere F., Byrnes L., Wagner A., McMorrow T., Gannon F.;
RT "Salmon HNF1: cDNA sequence, evolution, tissue specificity and binding to
RT the salmon serum albumin promoter.";
RL J. Mol. Biol. 247:1-10(1995).
CC -!- FUNCTION: Transcriptional activator that regulates the tissue specific
CC expression of multiple genes, especially in pancreas and liver (By
CC similarity). Binds to the promoter of the albumin gene. {ECO:0000250,
CC ECO:0000269|PubMed:7897653}.
CC -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in liver, intestine, spleen and kidney.
CC {ECO:0000269|PubMed:7897653}.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
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DR EMBL; X79486; CAA55985.1; -; mRNA.
DR PIR; S54358; S54358.
DR RefSeq; NP_001117146.1; NM_001123674.1.
DR AlphaFoldDB; Q91474; -.
DR SMR; Q91474; -.
DR STRING; 8030.ENSSSAP00000012471; -.
DR GeneID; 100136586; -.
DR KEGG; sasa:100136586; -.
DR CTD; 6927; -.
DR OrthoDB; 409935at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR006898; HNF1a_C.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; PTHR11568; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04813; HNF-1A_C; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..559
FT /note="Hepatocyte nuclear factor 1-alpha"
FT /id="PRO_0000049126"
FT DOMAIN 13..44
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 78..173
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 188..268
FT /note="Homeobox; HNF1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 14..43
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..123
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 134..140
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 146..149
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 192..195
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 252..254
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 259..262
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 492..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 186..194
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 61531 MW; 0ED56EA24022DAF4 CRC64;
MEGEERKGEA GPGPGRLSAL QEQLIWALLG SGLSREVLVH ALGELERERV TPGAEKGDRG
DGESSEEGEM DFPPPIFQEL EALAPEEAAR QRALVDQLLQ EDPWRVAKLV KSYMQQHNLP
QREVVESIGL NQSHLSQHLN KGTPMKNQKR AALYSWYVRK QGEISQQFTN ARHALGSGEE
QGEDVRKGRR NRFKWGPASQ QILFHAYERQ RNPSKEEREG LVEECNRAEC LQRGVSPSQL
AGLGSNLVTE VRVYNWFANR RKEEAFRHKL ALDMPYNSQS ASSTNHTLSH SPEQGMKYSQ
QITCDNLGSS RGHNGDRGLG GRLASPIQLE PSHTLLETHH HKPVSGGGPL PPVSTLTSLH
SLSASPAPHH GLIMTSLPSV MSLGESSLLI GQTVPVINNV GGGFTTLQPI SFQQQLHSTS
QQQLTQQFQS HMGHHHSPFM ATMAQLPCHM YSKSDMSHYP PSSLLSQAMV ITDSSSLGTL
TSLTTVRQIL TTDPEEQTDQ PIQEDSLHLQ SPSPVPVSSG NLQLYPPSQS SESHPPHRLS
SSPADINSYI PAQMVSTAQ
