ID   HNF4B_XENLA             Reviewed;         446 AA.
AC   P79926;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Hepatocyte nuclear factor 4-beta;
DE            Short=HNF-4-beta;
DE   AltName: Full=Nuclear receptor subfamily 2 group A member 3;
GN   Name=hnf4b; Synonyms=nr2a3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=9001222; DOI=10.1128/mcb.17.2.687;
RA   Holewa B., Zapp D., Drewes T., Senkel S., Ryffel G.U.;
RT   "HNF4beta, a new gene of the HNF4 family with distinct activation and
RT   expression profiles in oogenesis and embryogenesis of Xenopus laevis.";
RL   Mol. Cell. Biol. 17:687-694(1997).
CC   -!- FUNCTION: Transcription factor; binds and activates the promoter for
CC       the HNF1-alpha gene. Seems to have a lower DNA binding activity than
CC       HNF4-alpha and is a weaker transactivator than the alpha isoform.
CC   -!- SUBUNIT: Homodimerization is required for HNF4-alpha to bind to its
CC       recognition site. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- TISSUE SPECIFICITY: Expressed in liver, kidney, stomach, intestine,
CC       lung, ovary, and testis. Not expressed in fat, muscle and brain.
CC   -!- DEVELOPMENTAL STAGE: Maternal protein which is distributed within an
CC       animal-to-vegetal gradient in the embryo. Present from the egg stage
CC       onward and throughout the entire development.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; Z49827; CAA89991.1; -; mRNA.
DR   AlphaFoldDB; P79926; -.
DR   SMR; P79926; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003707; F:nuclear steroid receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR000003; Retinoid-X_rcpt/HNF4.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00545; RETINOIDXR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..446
FT                   /note="Hepatocyte nuclear factor 4-beta"
FT                   /id="PRO_0000053564"
FT   DOMAIN          137..366
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        47..122
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         50..70
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         86..110
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   446 AA;  50257 MW;  854FF260834DF18D CRC64;
     MDMPDYTETL DSSYTMLEFD SIRVLPSNTE IITVETASPG LLNNGINSFC AICGDRATGK
     HYGASSCDGC KGFFRRSVRK NHVYACRFSR QCIVDKDKRN QCRYCRLRKC FRAGMKKEAV
     QNERDRISMR RSSYEDNGSL SINVLTQAEA MVHQYSPVSP VHSSDISMKK VASISDVCES
     MKQQLLLLVE WAKYIPAFCE LPLDDQVALL RAHAGAHLLL GVAKRSLPYK DFLLLGNDFI
     MPMHCPELEI ARVPCRILDE LVKPLREIQI DDNEYVCLKA IIFFDPDCKG LSDQTKVKNM
     RFQVQVNLED YINDRQFDSR GRFSDILLLL PPLQSITWQM IEQVQFAKLF GVARIDSLLQ
     ELLLGGTTMD GGQYINSGHS SLNLDLLPGP TVHSHNLHSV IHTVSSLSPE TSPPTNSTSE
     DYKMNTATVS SIPLMQRTVI AKKEIL