ID   3SOK1_HEMHA             Reviewed;          57 AA.
AC   P01402;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Weak toxin CM-1b {ECO:0000303|PubMed:7394807};
OS   Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Hemachatus.
OX   NCBI_TaxID=8626;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=7394807; DOI=10.1016/0041-0101(80)90073-2;
RA   Joubert F.J., Taljaard N.;
RT   "The complete primary structure of toxin CM-1b from Hemachatus haemachatus
RT   (Ringhals) snake venom.";
RL   Toxicon 18:191-198(1980).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7394807}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 11.7 mg/kg by intravenous injection.
CC       {ECO:0000269|PubMed:7394807}.
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 28 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XX sub-subfamily. {ECO:0000305}.
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DR   PIR; A01673; T2NJBE.
DR   AlphaFoldDB; P01402; -.
DR   SMR; P01402; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..57
FT                   /note="Weak toxin CM-1b"
FT                   /evidence="ECO:0000269|PubMed:7394807"
FT                   /id="PRO_0000093626"
FT   DISULFID        3..19
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        12..37
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        40..49
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        50..55
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   57 AA;  6630 MW;  63D1C7818A8B2E20 CRC64;
     LECYQKSKVV TCQPEQKFCY SDTMTFFPNH PVYLSGCTFC RTDESGERCC TTDRCNK