ID   HNS_BUCAI               Reviewed;         135 AA.
AC   P57360;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA-binding protein H-NS homolog;
GN   Name=hns; OrderedLocusNames=BU272;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: A DNA-binding protein implicated in transcriptional
CC       repression and chromosome organization and compaction. Binds nucleation
CC       sites in AT-rich DNA and bridges them, forming higher-order
CC       nucleoprotein complexes and condensing the chromosome. A subset of
CC       genes are repressed by H-NS in association with other proteins (By
CC       similarity). {ECO:0000250|UniProtKB:P0ACF8}.
CC   -!- SUBUNIT: Homodimer that oligomerizes on DNA into higher-order complexes
CC       that form bridges between disparate regions of DNA compacting it.
CC       {ECO:0000250|UniProtKB:P0ACF8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000250|UniProtKB:P0ACF8}.
CC   -!- SIMILARITY: Belongs to the histone-like protein H-NS family.
CC       {ECO:0000305}.
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DR   EMBL; BA000003; BAB12982.1; -; Genomic_DNA.
DR   RefSeq; NP_240096.1; NC_002528.1.
DR   RefSeq; WP_009874226.1; NC_002528.1.
DR   AlphaFoldDB; P57360; -.
DR   SMR; P57360; -.
DR   STRING; 107806.10038947; -.
DR   EnsemblBacteria; BAB12982; BAB12982; BAB12982.
DR   KEGG; buc:BU272; -.
DR   PATRIC; fig|107806.10.peg.282; -.
DR   eggNOG; COG2916; Bacteria.
DR   HOGENOM; CLU_117503_0_0_6; -.
DR   OMA; NGVEKTW; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.287.1050; -; 1.
DR   Gene3D; 4.10.430.10; -; 1.
DR   InterPro; IPR027444; H-NS_C_dom.
DR   InterPro; IPR037150; H-NS_C_dom_sf.
DR   InterPro; IPR001801; Histone_HNS.
DR   InterPro; IPR027454; Histone_HNS_N.
DR   Pfam; PF00816; Histone_HNS; 1.
DR   PIRSF; PIRSF002096; HnS; 1.
DR   SMART; SM00528; HNS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..135
FT                   /note="DNA-binding protein H-NS homolog"
FT                   /id="PRO_0000168502"
FT   DNA_BIND        112..117
FT                   /evidence="ECO:0000250|UniProtKB:P0A1S2"
SQ   SEQUENCE   135 AA;  16005 MW;  2D46B9A2E752BD68 CRC64;
     MNEILKILNN IRTLRVHSRE CSLEILEEIL EKFKVVINER KKEEKKIKEE IAQRAIKLKK
     YREMLIADGI NPNELLTKTN SIKSSEKRKR PKRPAKYKYI NKNGDFKTWT GQGRTPSVIK
     NAILERKKIL EDFLL