HNS_HAEIN
ID HNS_HAEIN Reviewed; 134 AA.
AC P43841;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=DNA-binding protein H-NS homolog;
GN Name=hns; OrderedLocusNames=HI_1587;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: A DNA-binding protein implicated in transcriptional
CC repression and chromosome organization and compaction. Binds nucleation
CC sites in AT-rich DNA and bridges them, forming higher-order
CC nucleoprotein complexes and condensing the chromosome. As many
CC horizontally transferred genes are AT-rich, it plays a central role in
CC silencing foreign genes. A subset of genes are repressed by H-NS in
CC association with other proteins (By similarity).
CC {ECO:0000250|UniProtKB:P0ACF8}.
CC -!- SUBUNIT: Homodimer that oligomerizes on DNA into higher-order complexes
CC that form bridges between disparate regions of DNA compacting it.
CC {ECO:0000250|UniProtKB:P0ACF8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC {ECO:0000250|UniProtKB:P0ACF8}.
CC -!- SIMILARITY: Belongs to the histone-like protein H-NS family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC23235.1; -; Genomic_DNA.
DR PIR; D64131; D64131.
DR RefSeq; NP_439732.1; NC_000907.1.
DR RefSeq; WP_005647241.1; NC_000907.1.
DR AlphaFoldDB; P43841; -.
DR SMR; P43841; -.
DR STRING; 71421.HI_1587; -.
DR EnsemblBacteria; AAC23235; AAC23235; HI_1587.
DR KEGG; hin:HI_1587; -.
DR PATRIC; fig|71421.8.peg.1661; -.
DR eggNOG; COG2916; Bacteria.
DR HOGENOM; CLU_117503_0_0_6; -.
DR OMA; NTWLELM; -.
DR PhylomeDB; P43841; -.
DR BioCyc; HINF71421:G1GJ1-1603-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR GO; GO:0003681; F:bent DNA binding; IBA:GO_Central.
DR GO; GO:0001217; F:DNA-binding transcription repressor activity; IBA:GO_Central.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR Gene3D; 1.10.287.1050; -; 1.
DR Gene3D; 4.10.430.10; -; 1.
DR InterPro; IPR027444; H-NS_C_dom.
DR InterPro; IPR037150; H-NS_C_dom_sf.
DR InterPro; IPR001801; Histone_HNS.
DR InterPro; IPR027454; Histone_HNS_N.
DR Pfam; PF00816; Histone_HNS; 1.
DR PIRSF; PIRSF002096; HnS; 1.
DR SMART; SM00528; HNS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..134
FT /note="DNA-binding protein H-NS homolog"
FT /id="PRO_0000168506"
FT DNA_BIND 112..117
FT /evidence="ECO:0000250|UniProtKB:P0A1S2"
FT REGION 106..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 134 AA; 15328 MW; F57CBA0C1496900B CRC64;
MNELVRGLTN LRSLRAAVRE LTLEQAENAL EKLQTAIEEK RANEAELIKA ETERKERLAK
YKELMEKEGI TPEELHEIFG TKTVSIRAKR APRPAKYAFI DENGEHKTWT GQGRTPRPIQ
NALNKGKSLS DFEI
