ID   3SOK2_NAJHA             Reviewed;          61 AA.
AC   P25678;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Weak toxin CM-2a;
OS   Naja annulifera (Banded Egyptian cobra) (Naja haje annulifera).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=96794;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=852822; DOI=10.1515/bchm2.1977.358.1.377;
RA   Joubert F.J.;
RT   "Snake venom toxins. The amino acid sequences of two toxins (CM-2a and CM-
RT   3) from Naja haje annulifera (Egyptian cobra) venom.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 358:377-390(1977).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:852822}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 15.4 mg/kg by intravenous injection.
CC       {ECO:0000269|PubMed:852822}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XX sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P25678; -.
DR   SMR; P25678; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..61
FT                   /note="Weak toxin CM-2a"
FT                   /evidence="ECO:0000269|PubMed:852822"
FT                   /id="PRO_0000093628"
FT   DISULFID        3..19
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        12..37
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        41..49
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        50..55
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   61 AA;  6837 MW;  163467B6DACBC23A CRC64;
     LECYQMSKVV TCKPEETFCY SDVFMPFRNH IVYTSGCSSY CRDGTGEKCC TTDRCNGARG
     G