AOFB_DICDI
ID AOFB_DICDI Reviewed; 471 AA.
AC Q556K3; Q86AM6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Probable flavin-containing monoamine oxidase B;
DE EC=1.4.3.4;
GN Name=maoB-1; ORFNames=DDB_G0272582;
GN and
GN Name=maoB-2; ORFNames=DDB_G0273993;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an
CC aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478,
CC ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70430.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70928.1; -; Genomic_DNA.
DR RefSeq; XP_644355.1; XM_639263.1.
DR RefSeq; XP_645059.1; XM_639967.1.
DR AlphaFoldDB; Q556K3; -.
DR SMR; Q556K3; -.
DR STRING; 44689.DDB0231711; -.
DR PaxDb; Q556K3; -.
DR EnsemblProtists; EAL70430; EAL70430; DDB_G0273993.
DR EnsemblProtists; EAL70928; EAL70928; DDB_G0272582.
DR GeneID; 8618734; -.
DR GeneID; 8619242; -.
DR KEGG; ddi:DDB_G0272582; -.
DR KEGG; ddi:DDB_G0273993; -.
DR dictyBase; DDB_G0272582; maoB-1.
DR dictyBase; DDB_G0273993; maoB-2.
DR eggNOG; KOG0029; Eukaryota.
DR HOGENOM; CLU_004498_0_4_1; -.
DR InParanoid; Q556K3; -.
DR OMA; IGPGQDR; -.
DR PhylomeDB; Q556K3; -.
DR Reactome; R-DDI-3214842; HDMs demethylate histones.
DR PRO; PR:Q556K3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0046592; F:polyamine oxidase activity; IBA:GO_Central.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR Pfam; PF01593; Amino_oxidase; 1.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT CHAIN 1..471
FT /note="Probable flavin-containing monoamine oxidase B"
FT /id="PRO_0000328629"
FT MOD_RES 406
FT /note="S-8alpha-FAD cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 471 AA; 53612 MW; 76D9EF17F67950F0 CRC64;
MEMEILYNYD TIIIGGGLSG LNTAYDLKKS NFKILVLEAR NRFGGRTDSV KVGDGWVDAG
GQWLGTNNPN LKQLCKELKL ETYKQFYQGK TVFDIYDDGL IKSFDESSPN FDLCEIGLGN
INPIIRAIKE VMKNIDFSKC SKESPIMLSL EKLTVSEWLR VCGYGESVKF FNWFCKMSVA
SSSDDISILF LLKYVNSING FESLFISDDD CTESDRIIGG SSMVSERIVS YLKDDCKLNC
EVTLIDQISH KNSRLIKITT SNNENYYCRN VVSTIPPMLL KNVIFKPDLP IEKQRLKNEM
EMGNTIKVIV IYDSVFWRDQ GYNGKSQSFV GPIYQSFDNC TNDLSVKSII GFINGKEEIK
YWYSKSLEER RSAVLNQYSK YWGPKALNPI HYIERNWSLD KYSAGCFMGV CKSGDIISQC
NNYYTQPHGN IHWAGTETST QWYGHMEGAI TSSKRVVNEI LKNSLNSKSK L
