ID   HOATZ_DANRE             Reviewed;         164 AA.
AC   A5PN52;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Cilia- and flagella-associated protein HOATZ {ECO:0000250|UniProtKB:Q80Y73};
GN   Name=hoatz; ORFNames=si:dkey-27p23.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May be required for motile ciliogenesis and flagellar
CC       genesis. {ECO:0000250|UniProtKB:Q80Y73}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80Y73}. Cell
CC       projection, cilium {ECO:0000250|UniProtKB:Q80Y73}.
CC   -!- SIMILARITY: Belongs to the HOATZ family. {ECO:0000305}.
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DR   EMBL; BX950179; CAN88251.1; -; Genomic_DNA.
DR   RefSeq; NP_001093491.2; NM_001100021.2.
DR   AlphaFoldDB; A5PN52; -.
DR   STRING; 7955.ENSDARP00000122168; -.
DR   PaxDb; A5PN52; -.
DR   Ensembl; ENSDART00000132376; ENSDARP00000122168; ENSDARG00000075714.
DR   GeneID; 566423; -.
DR   KEGG; dre:566423; -.
DR   CTD; 399949; -.
DR   ZFIN; ZDB-GENE-070705-453; hoatz.
DR   eggNOG; ENOG502S8UY; Eukaryota.
DR   GeneTree; ENSGT00940000166624; -.
DR   HOGENOM; CLU_122904_1_0_1; -.
DR   InParanoid; A5PN52; -.
DR   OMA; MYPPNES; -.
DR   OrthoDB; 1614119at2759; -.
DR   PhylomeDB; A5PN52; -.
DR   PRO; PR:A5PN52; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000075714; Expressed in testis and 11 other tissues.
DR   ExpressionAtlas; A5PN52; baseline.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   InterPro; IPR040681; HOATZ-like.
DR   PANTHER; PTHR47231; PTHR47231; 1.
DR   Pfam; PF17664; HOATZ-like; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Reference proteome.
FT   CHAIN           1..164
FT                   /note="Cilia- and flagella-associated protein HOATZ"
FT                   /id="PRO_0000360983"
FT   REGION          132..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   164 AA;  19187 MW;  E265AD88D2C8E20B CRC64;
     MSEELDEEVL DGLTEVEKLY TVFHGASQED VAYAKLFWNS LSLQPPIESR LVSSDIRQRL
     KVAKTPNTTN AAANQAPWSK RNEEIQQDAY LRQKQEEKQR YMEMAKNRDQ IIALLKKQRD
     ERIKKEMIAY KHKPKKGKLE EKRLAPKTLS SDVDEDQKEV QKLQ