ID   AOFC_DICDI              Reviewed;         467 AA.
AC   Q556K4; Q86AM5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Probable flavin-containing monoamine oxidase C;
DE            EC=1.4.3.4;
GN   Name=maoC-1; ORFNames=DDB_G0272584;
GN   and
GN   Name=maoC-2; ORFNames=DDB_G0273991;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an
CC         aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70429.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70929.1; -; Genomic_DNA.
DR   RefSeq; XP_644354.1; XM_639262.1.
DR   RefSeq; XP_645060.1; XM_639968.1.
DR   AlphaFoldDB; Q556K4; -.
DR   SMR; Q556K4; -.
DR   STRING; 44689.DDB0231712; -.
DR   PaxDb; Q556K4; -.
DR   EnsemblProtists; EAL70429; EAL70429; DDB_G0273991.
DR   EnsemblProtists; EAL70929; EAL70929; DDB_G0272584.
DR   GeneID; 8618735; -.
DR   GeneID; 8619241; -.
DR   KEGG; ddi:DDB_G0272584; -.
DR   KEGG; ddi:DDB_G0273991; -.
DR   dictyBase; DDB_G0272584; maoC-1.
DR   dictyBase; DDB_G0273991; maoC-2.
DR   eggNOG; KOG0029; Eukaryota.
DR   HOGENOM; CLU_004498_0_4_1; -.
DR   InParanoid; Q556K4; -.
DR   PhylomeDB; Q556K4; -.
DR   Reactome; R-DDI-3214842; HDMs demethylate histones.
DR   PRO; PR:Q556K4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0097621; F:monoamine oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0046592; F:polyamine oxidase activity; IBA:GO_Central.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR001613; Flavin_amine_oxidase.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   PRINTS; PR00757; AMINEOXDASEF.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..467
FT                   /note="Probable flavin-containing monoamine oxidase C"
FT                   /id="PRO_0000328630"
FT   MOD_RES         402
FT                   /note="S-8alpha-FAD cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   467 AA;  53140 MW;  1D6FC3750E9C223E CRC64;
     MEIIYDTIII GGGMSGLKTA YDLKKSNFKI LVLEARNRFG GRTDSIKIGD GWVDAGGQWL
     GKKNPNLKQL CNELKLETYK QFYQGKTVFD IYDDGLIKSF DESSPNFDLC EIGLGYINPI
     IQTIKEVGKN IDFSKCSKES PIMLSLEKLT VSEWLRVCGY GESVKFFIWF CKMSVASSSD
     DISILFFFKY INSINGIESL FISDDDCTES DRIIGGSSMV SERIVSFLKD DCKLNCEVTL
     IDQISHKNGR LVKITTSKNE IYYCRNVVST IPPMLLKNVI FKPDLPIEKQ RLKNEMEMGN
     TIKVIVIYDS VFWRDQGYNG KSQSFVGPIY QSFDNCTNDL SVKSIIGFIN GKEEIKYWYS
     KSLEERRSAV LNQYSKYWGP KALNPIHYIE RNWSLDKYSA GCFMGVCKSG DIISQCNNYY
     TQPHGNIHWA GTETSTQWYG HMEGAITSSK RVVNEILKTS LKSKSKL