HOFC_ECOLI
ID HOFC_ECOLI Reviewed; 400 AA.
AC P36646; P75648; Q47020; Q47021;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Protein transport protein HofC homolog;
GN Name=hofC; Synonyms=hopC, yacD; OrderedLocusNames=b0106, JW0102;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=7959070; DOI=10.1016/0378-1119(94)90851-6;
RA Whitchurch C.B., Mattick J.S.;
RT "Escherichia coli contains a set of genes homologous to those involved in
RT protein secretion, DNA uptake and the assembly of type-4 fimbriae in other
RT bacteria.";
RL Gene 150:9-15(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8202364; DOI=10.1093/nar/22.9.1637;
RA Fujita N., Mori H., Yura T., Ishihama A.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-
RT 4.1 min (110,917-193,643 bp) region.";
RL Nucleic Acids Res. 22:1637-1639(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 165-400.
RC STRAIN=K12;
RX PubMed=2904262; DOI=10.1042/bj2550035;
RA Andrews S.C., Guest J.R.;
RT "Nucleotide sequence of the gene encoding the GMP reductase of Escherichia
RT coli K12.";
RL Biochem. J. 255:35-43(1988).
RN [6]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the GSP F family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=X07917; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; L28105; AAC36925.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73217.1; -; Genomic_DNA.
DR EMBL; AP009048; BAB96674.2; -; Genomic_DNA.
DR EMBL; X07917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; B64733; B64733.
DR RefSeq; NP_414648.1; NC_000913.3.
DR RefSeq; WP_000157266.1; NZ_SSZK01000004.1.
DR AlphaFoldDB; P36646; -.
DR SMR; P36646; -.
DR BioGRID; 4261120; 155.
DR STRING; 511145.b0106; -.
DR PaxDb; P36646; -.
DR PRIDE; P36646; -.
DR EnsemblBacteria; AAC73217; AAC73217; b0106.
DR EnsemblBacteria; BAB96674; BAB96674; BAB96674.
DR GeneID; 945806; -.
DR KEGG; ecj:JW0102; -.
DR KEGG; eco:b0106; -.
DR PATRIC; fig|1411691.4.peg.2176; -.
DR EchoBASE; EB1746; -.
DR eggNOG; COG1459; Bacteria.
DR HOGENOM; CLU_035032_2_0_6; -.
DR InParanoid; P36646; -.
DR OMA; IYRTFNT; -.
DR PhylomeDB; P36646; -.
DR BioCyc; EcoCyc:EG11798-MON; -.
DR PRO; PR:P36646; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015628; P:protein secretion by the type II secretion system; IBA:GO_Central.
DR Gene3D; 1.20.81.30; -; 2.
DR InterPro; IPR003004; GspF/PilC.
DR InterPro; IPR001992; T2SS_GspF/T4SS_PilC_CS.
DR InterPro; IPR018076; T2SS_GspF_dom.
DR InterPro; IPR042094; T2SS_GspF_sf.
DR PANTHER; PTHR30012; PTHR30012; 1.
DR Pfam; PF00482; T2SSF; 2.
DR PRINTS; PR00812; BCTERIALGSPF.
DR PROSITE; PS00874; T2SP_F; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..400
FT /note="Protein transport protein HofC homolog"
FT /id="PRO_0000207845"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 1..39
FT /note="MASKQLWRWHGITGDGNAQDGMLWAESRTLLLMALQQQM -> MAVSNSGAG
FT MAYAQVVLTT (in Ref. 1; AAC36925)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 400 AA; 44450 MW; 9D37332B87AE07D5 CRC64;
MASKQLWRWH GITGDGNAQD GMLWAESRTL LLMALQQQMV TPLSLKRIAI NSAQWRGDKS
AEVIHQLATL LKAGLTLSEG LALLAEQHPS KQWQALLQSL AHDLEQGIAF SNALLPWSEV
FPPLYQAMIR TGELTGKLDE CCFELARQQK AQRQLTDKVK SALRYPIIIL AMAIMVVVAM
LHFVLPEFAA IYKTFNTPLP ALTQGIMTLA DFSGEWSWLL VLFGFLLAIA NKLLMRRPTW
LIVRQKLLLR IPIMGSLMRG QKLTQIFTIL ALTQSAGITF LQGVESVRET MRCPYWVQLL
TQIQHDISNG QPIWLALKNT GEFSPLCLQL VRTGEASGSL DLMLDNLAHH HRENTMALAD
NLAALLEPAL LIITGGIIGT LVVAMYLPIF HLGDAMSGMG
