ID   HOFM_ECOLI              Reviewed;         259 AA.
AC   P45753; Q2M760;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=DNA utilization protein HofM;
GN   Name=hofM; Synonyms=yrfD; OrderedLocusNames=b3395, JW5693;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / W3110 / ZK126;
RX   PubMed=16707682; DOI=10.1128/jb.01974-05;
RA   Palchevskiy V., Finkel S.E.;
RT   "Escherichia coli competence gene homologs are essential for competitive
RT   fitness and the use of DNA as a nutrient.";
RL   J. Bacteriol. 188:3902-3910(2006).
CC   -!- FUNCTION: Required for the use of extracellular DNA as a nutrient.
CC       {ECO:0000269|PubMed:16707682}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are unable to use DNA as a sole carbon
CC       and energy source. They do not show a growth disadvantage in stationary
CC       phase growth in cocultures with wild-type.
CC       {ECO:0000269|PubMed:16707682}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA58192.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U18997; AAA58192.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76420.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77896.1; -; Genomic_DNA.
DR   PIR; F65134; F65134.
DR   RefSeq; NP_417854.4; NC_000913.3.
DR   RefSeq; WP_001295166.1; NZ_SSZK01000008.1.
DR   AlphaFoldDB; P45753; -.
DR   SMR; P45753; -.
DR   BioGRID; 4260909; 9.
DR   DIP; DIP-12921N; -.
DR   IntAct; P45753; 2.
DR   STRING; 511145.b3395; -.
DR   PaxDb; P45753; -.
DR   PRIDE; P45753; -.
DR   EnsemblBacteria; AAC76420; AAC76420; b3395.
DR   EnsemblBacteria; BAE77896; BAE77896; BAE77896.
DR   GeneID; 947908; -.
DR   KEGG; ecj:JW5693; -.
DR   KEGG; eco:b3395; -.
DR   PATRIC; fig|1411691.4.peg.3335; -.
DR   EchoBASE; EB2761; -.
DR   eggNOG; COG4972; Bacteria.
DR   HOGENOM; CLU_083891_1_0_6; -.
DR   OMA; DGWQLRH; -.
DR   PhylomeDB; P45753; -.
DR   BioCyc; EcoCyc:G7739-MON; -.
DR   PRO; PR:P45753; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0015976; P:carbon utilization; IMP:EcoCyc.
DR   GO; GO:0006308; P:DNA catabolic process; IMP:EcoCyc.
DR   InterPro; IPR043129; ATPase_NBD.
DR   SUPFAM; SSF53067; SSF53067; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..259
FT                   /note="DNA utilization protein HofM"
FT                   /id="PRO_0000169541"
SQ   SEQUENCE   259 AA;  29000 MW;  B3E8B4A0E4AB166D CRC64;
     MAFKIWQIGL HLQQQEAVAV AIVRGAKECF LQRWWRLPLE NDIIKDGRIV DAQQLAKTLL
     PWSRELPQRH HIMLAFPASR TLQRSFPRPS MSLGEREQTA WLSGTMAREL DMDPDSLRFD
     YSEDSLSPAY NVTAAQSKEL ATLLTLAERL RVHVSAITPD ASALQRFLPF LPSHQQCLAW
     RDNEQWLWAT RYSWGRKLAV GMTSAKELAA ALSVDPESVA ICGEGGFDPW EAVSVRQPPL
     PPPGGDFAIA LGLALGKAY