ID   HOFN_SHIFL              Reviewed;         179 AA.
AC   P64635; P45752;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Putative DNA utilization protein HofN;
GN   Name=hofN; OrderedLocusNames=SF3412, S4350;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Required for the use of extracellular DNA as a nutrient.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE005674; AAN44873.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP19305.1; -; Genomic_DNA.
DR   RefSeq; NP_709166.1; NC_004337.2.
DR   RefSeq; WP_001069315.1; NZ_WPGW01000003.1.
DR   AlphaFoldDB; P64635; -.
DR   STRING; 198214.SF3412; -.
DR   EnsemblBacteria; AAN44873; AAN44873; SF3412.
DR   EnsemblBacteria; AAP19305; AAP19305; S4350.
DR   GeneID; 1025320; -.
DR   GeneID; 66672726; -.
DR   KEGG; sfl:SF3412; -.
DR   KEGG; sfx:S4350; -.
DR   PATRIC; fig|198214.7.peg.4027; -.
DR   HOGENOM; CLU_081304_2_0_6; -.
DR   OMA; HFTLRIT; -.
DR   OrthoDB; 1673053at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007813; PilN.
DR   Pfam; PF05137; PilN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..179
FT                   /note="Putative DNA utilization protein HofN"
FT                   /id="PRO_0000169540"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   179 AA;  20796 MW;  2A7D86A4B36B10C8 CRC64;
     MNPPINFLPW RQQRRTAFLR FWLLMFVAPL LLAVGITLIL RLTGSAEARI DAVLLQAEQQ
     LARSLQITKP RLLEQQQLRE QRSQRQRQRQ FTRDWQSALE ALAALLPEHA WLTTISWQQG
     TLEIKGLTTS ITALNALETS LRQDASFHLN QRGATQQDAQ GRWQFEYQLT RKVSDEHVL