ID   HOFP_ECOLI              Reviewed;         134 AA.
AC   P45750; Q2M757;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DNA utilization protein HofP;
GN   Name=hofP; Synonyms=yrfA; OrderedLocusNames=b3392, JW5694;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / W3110 / ZK126;
RX   PubMed=16707682; DOI=10.1128/jb.01974-05;
RA   Palchevskiy V., Finkel S.E.;
RT   "Escherichia coli competence gene homologs are essential for competitive
RT   fitness and the use of DNA as a nutrient.";
RL   J. Bacteriol. 188:3902-3910(2006).
CC   -!- FUNCTION: Required for the use of extracellular DNA as a nutrient.
CC       {ECO:0000269|PubMed:16707682}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are unable to use DNA as a sole carbon
CC       and energy source and show decreased competitive fitness when
CC       cocultured with wild-type cells. {ECO:0000269|PubMed:16707682}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA58189.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U18997; AAA58189.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76417.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77899.1; -; Genomic_DNA.
DR   PIR; C65134; C65134.
DR   RefSeq; NP_417851.4; NC_000913.3.
DR   RefSeq; WP_001264141.1; NZ_STEB01000004.1.
DR   AlphaFoldDB; P45750; -.
DR   BioGRID; 4261393; 8.
DR   STRING; 511145.b3392; -.
DR   PaxDb; P45750; -.
DR   PRIDE; P45750; -.
DR   EnsemblBacteria; AAC76417; AAC76417; b3392.
DR   EnsemblBacteria; BAE77899; BAE77899; BAE77899.
DR   GeneID; 66672728; -.
DR   GeneID; 947900; -.
DR   KEGG; ecj:JW5694; -.
DR   KEGG; eco:b3392; -.
DR   PATRIC; fig|1411691.4.peg.3338; -.
DR   EchoBASE; EB2758; -.
DR   eggNOG; ENOG50335JD; Bacteria.
DR   HOGENOM; CLU_128670_0_0_6; -.
DR   OMA; QWRYQGI; -.
DR   PhylomeDB; P45750; -.
DR   BioCyc; EcoCyc:G7736-MON; -.
DR   PRO; PR:P45750; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0015976; P:carbon utilization; IMP:EcoCyc.
DR   GO; GO:0006308; P:DNA catabolic process; IMP:EcoCyc.
DR   InterPro; IPR019684; HofP.
DR   Pfam; PF10748; HofP; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..134
FT                   /note="DNA utilization protein HofP"
FT                   /id="PRO_0000169537"
FT   REGION          95..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  15098 MW;  F6C5010E3127D056 CRC64;
     MRVKRWLLAG IALCLLTGMR DPFKPPEDLC RISELSQWRY QGMVGRGERI IGVIKDGQKK
     WRRVQQNDVL ENGWTILQLT PDVLTLGTGT NCEPPQWLWQ RQGDTNEAMD SRTTVDADTR
     RTGGKAAKSD ADGG