ID   HOKD_ECO57              Reviewed;          51 AA.
AC   P0ACG7; P07009; P77643; Q8X294;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein HokD;
GN   Name=hokD; OrderedLocusNames=Z3117.1, ECs2754;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system (By
CC       similarity). When overexpressed kills cells within minutes; causes
CC       collapse of the transmembrane potential and arrest of respiration (By
CC       similarity). Its toxic effect is probably neutralized by an antisense
CC       antitoxin Sok RNA (By similarity). {ECO:0000250|UniProtKB:P0ACG4}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Hok/Gef family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB36177.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BA000007; BAB36177.1; ALT_INIT; Genomic_DNA.
DR   PIR; B90973; B90973.
DR   RefSeq; NP_310781.1; NC_002695.1.
DR   RefSeq; WP_000813254.1; NZ_LKAL01000083.1.
DR   AlphaFoldDB; P0ACG7; -.
DR   SMR; P0ACG7; -.
DR   EnsemblBacteria; BAB36177; BAB36177; ECs_2754.
DR   GeneID; 60668608; -.
DR   GeneID; 67415730; -.
DR   GeneID; 912381; -.
DR   KEGG; ecs:ECs_2754; -.
DR   PATRIC; fig|386585.9.peg.2889; -.
DR   HOGENOM; CLU_177638_2_0_6; -.
DR   OMA; LRLMIIC; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000021; Hok/gef_toxin.
DR   InterPro; IPR018084; Hok/gef_toxin_CS.
DR   Pfam; PF01848; HOK_GEF; 1.
DR   PRINTS; PR00281; HOKGEFTOXIC.
DR   PROSITE; PS00556; HOK_GEF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT   CHAIN           1..51
FT                   /note="Protein HokD"
FT                   /id="PRO_0000199034"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   51 AA;  5737 MW;  927EDBDE60B61A27 CRC64;
     MKQQKAMLIA LIVICLTVIV TALVTRKDLC EVRIRTGQTE VAVFTAYEPE E