ID   HOKD_SHIFL              Reviewed;          51 AA.
AC   Q7UCD5;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Protein HokD;
DE   AltName: Full=Protein RelF;
GN   Name=hokD1; Synonyms=relF1; OrderedLocusNames=SF1547.1, S1668;
GN   and
GN   Name=hokD2; Synonyms=relF2; OrderedLocusNames=SF2042.1, S2143;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system (By
CC       similarity). When overexpressed kills cells within minutes; causes
CC       collapse of the transmembrane potential and arrest of respiration (By
CC       similarity). Its toxic effect is probably neutralized by an antisense
CC       antitoxin Sok RNA (By similarity). {ECO:0000250|UniProtKB:P0ACG4}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Hok/Gef family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP17409.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE014073; AAP17027.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17409.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000813254.1; NZ_WPGV01000221.1.
DR   AlphaFoldDB; Q7UCD5; -.
DR   SMR; Q7UCD5; -.
DR   EnsemblBacteria; AAP17027; AAP17027; S1668.
DR   EnsemblBacteria; AAP17409; AAP17409; S2143.
DR   GeneID; 60668608; -.
DR   GeneID; 67415730; -.
DR   KEGG; sfx:S1668; -.
DR   KEGG; sfx:S2143; -.
DR   PATRIC; fig|623.156.peg.374; -.
DR   HOGENOM; CLU_177638_2_0_6; -.
DR   OrthoDB; 1959933at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000021; Hok/gef_toxin.
DR   InterPro; IPR018084; Hok/gef_toxin_CS.
DR   Pfam; PF01848; HOK_GEF; 1.
DR   PRINTS; PR00281; HOKGEFTOXIC.
DR   PROSITE; PS00556; HOK_GEF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT   CHAIN           1..51
FT                   /note="Protein HokD"
FT                   /id="PRO_0000199035"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   51 AA;  5737 MW;  927EDBDE60B61A27 CRC64;
     MKQQKAMLIA LIVICLTVIV TALVTRKDLC EVRIRTGQTE VAVFTAYEPE E