ID   HOLA_BUCAI              Reviewed;         331 AA.
AC   P57520;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=DNA polymerase III subunit delta;
DE            EC=2.7.7.7;
GN   Name=holA; OrderedLocusNames=BU445;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity. The delta
CC       subunit seems to interact with the gamma subunit to transfer the beta
CC       subunit on the DNA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; BA000003; BAB13143.1; -; Genomic_DNA.
DR   RefSeq; NP_240257.1; NC_002528.1.
DR   RefSeq; WP_009874399.1; NC_002528.1.
DR   AlphaFoldDB; P57520; -.
DR   SMR; P57520; -.
DR   STRING; 107806.10039109; -.
DR   EnsemblBacteria; BAB13143; BAB13143; BAB13143.
DR   KEGG; buc:BU445; -.
DR   PATRIC; fig|107806.10.peg.455; -.
DR   eggNOG; COG1466; Bacteria.
DR   HOGENOM; CLU_044694_0_2_6; -.
DR   OMA; RIPTGKP; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR032780; DNA_pol3_delt_C.
DR   InterPro; IPR010372; DNA_pol3_delta_N.
DR   InterPro; IPR005790; DNA_polIII_delta.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF14840; DNA_pol3_delt_C; 1.
DR   Pfam; PF06144; DNA_pol3_delta; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01128; holA; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..331
FT                   /note="DNA polymerase III subunit delta"
FT                   /id="PRO_0000105502"
SQ   SEQUENCE   331 AA;  40359 MW;  4C87B19DA31493FD CRC64;
     MKNIYPNELK KSLMQKLHYF YIFLGEDFFL LEKNQDMILN FAYKKGFLEK IIIDVEKNQD
     WKKIILFYKT NNLFFKKTTL VINFLIKKLN VILIQNLNKM FSLLHPDILI ILKFNHLSRF
     IQKNKSLKEF KNYNIVSCFT PYNLNFINWI KYEIQEKKIN IEEKAFFLLC KYYEGNTLFI
     YKILDMLFII WPDTCITEKK IKKIIIEFFD VSPSYWINSI FQGKTEKSFY ILNIFFKKKY
     NPLILVRSLQ KDLLQLIHMK REKKISIYVM LEKYNIFVTR RKFFIKAFNK INNDSLLKAI
     QILVKIEVNI KKKYNNYVWN QLQELILILC N