HOLA_BUCAP
ID HOLA_BUCAP Reviewed; 338 AA.
AC Q8K9B8;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=DNA polymerase III subunit delta;
DE EC=2.7.7.7;
GN Name=holA; OrderedLocusNames=BUsg_430;
OS Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=198804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sg;
RX PubMed=12089438; DOI=10.1126/science.1071278;
RA Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT "50 million years of genomic stasis in endosymbiotic bacteria.";
RL Science 296:2376-2379(2002).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity. The delta
CC subunit seems to interact with the gamma subunit to transfer the beta
CC subunit on the DNA (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III complex
CC (By similarity). {ECO:0000250}.
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DR EMBL; AE013218; AAM67973.1; -; Genomic_DNA.
DR RefSeq; WP_011053940.1; NC_004061.1.
DR AlphaFoldDB; Q8K9B8; -.
DR SMR; Q8K9B8; -.
DR STRING; 198804.BUsg_430; -.
DR EnsemblBacteria; AAM67973; AAM67973; BUsg_430.
DR KEGG; bas:BUsg_430; -.
DR eggNOG; COG1466; Bacteria.
DR HOGENOM; CLU_044694_0_2_6; -.
DR OMA; RIPTGKP; -.
DR OrthoDB; 1199768at2; -.
DR Proteomes; UP000000416; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR032780; DNA_pol3_delt_C.
DR InterPro; IPR010372; DNA_pol3_delta_N.
DR InterPro; IPR005790; DNA_polIII_delta.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF14840; DNA_pol3_delt_C; 1.
DR Pfam; PF06144; DNA_pol3_delta; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01128; holA; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW Transferase.
FT CHAIN 1..338
FT /note="DNA polymerase III subunit delta"
FT /id="PRO_0000105503"
SQ SEQUENCE 338 AA; 40430 MW; 600B449B547721B3 CRC64;
MKIIYPEELK QKLIKKLNYF YILLGEDSIL LSKAEQLIFY FAKDKKFIEK NTINIEKSTD
WNKVINFHKS KNLFFKKTIL IINFTIKKLN LSLVKNINKI PLFKNKDILT VIKLNALSSL
IKKSTILKIL ILESEIIYCS TPYEWAFKKW LQYEIKTRNL KITQESFLLL HKYYEGNTLC
LNQILDILSI TWPNENIKIE KIKKIINQFS IFSPVNWINA IFNKNKKKAI YILDSFFKQK
YNPLILIRTL QKDLLILLNM KREKKLNINF FLKKNNISLN RSKFFANALY YIDFNNFLKI
IRILLQIEIK IKKEYNNSVW IQLKTLTLLL SSPMKYTP
