HOLA_BUCBP
ID HOLA_BUCBP Reviewed; 332 AA.
AC Q89AC0;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=DNA polymerase III subunit delta;
DE EC=2.7.7.7;
GN Name=holA; OrderedLocusNames=bbp_396;
OS Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=224915;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bp;
RX PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT "Reductive genome evolution in Buchnera aphidicola.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity. The delta
CC subunit seems to interact with the gamma subunit to transfer the beta
CC subunit on the DNA (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III complex
CC (By similarity). {ECO:0000250}.
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DR EMBL; AE016826; AAO27108.1; -; Genomic_DNA.
DR RefSeq; WP_011091509.1; NC_004545.1.
DR AlphaFoldDB; Q89AC0; -.
DR SMR; Q89AC0; -.
DR STRING; 224915.bbp_396; -.
DR PRIDE; Q89AC0; -.
DR EnsemblBacteria; AAO27108; AAO27108; bbp_396.
DR GeneID; 56470933; -.
DR KEGG; bab:bbp_396; -.
DR eggNOG; COG1466; Bacteria.
DR HOGENOM; CLU_044694_0_2_6; -.
DR OMA; RIPTGKP; -.
DR OrthoDB; 1199768at2; -.
DR Proteomes; UP000000601; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR032780; DNA_pol3_delt_C.
DR InterPro; IPR010372; DNA_pol3_delta_N.
DR InterPro; IPR005790; DNA_polIII_delta.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF14840; DNA_pol3_delt_C; 1.
DR Pfam; PF06144; DNA_pol3_delta; 1.
DR SUPFAM; SSF48019; SSF48019; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01128; holA; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1..332
FT /note="DNA polymerase III subunit delta"
FT /id="PRO_0000105504"
SQ SEQUENCE 332 AA; 39291 MW; 97B14F10E2A67457 CRC64;
MKIIHSENLF SYSFKTLSSY YVIVGNVKHL IQQSTNIILN LAKKNGFSKM SKIIFCDPIY
INNIILSAKS QNLFFKKKII SISFKKYISI KEVQNYILKL KKYLHTNLLL IIYIYSTNTN
ILNKINTKIF PPNGTMITCT FFNQNNISIW TKYKIKNIKM NITKNAENLL IQYHQGNVLH
LNNTLNILSL VWKNKLINTL SITNFIEDCS IFKPLQWINA LLNNNLQFSI KILNQFENQN
FNPIILIRYL QHDLLTILLI KRDDVKNYYN ILKNRNTNKN RHSLIINYAR RKHYKTIYKS
IKLLTLIELQ IKKNNTKLIW LPFYTLSIII CL
