ID   HOLA_HAEIN              Reviewed;         344 AA.
AC   P43747;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DNA polymerase III subunit delta;
DE            EC=2.7.7.7;
GN   Name=holA; OrderedLocusNames=HI_0923;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity. The delta
CC       subunit seems to interact with the gamma subunit to transfer the beta
CC       subunit on the DNA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; L42023; AAC22583.1; -; Genomic_DNA.
DR   PIR; A64103; A64103.
DR   RefSeq; NP_439083.1; NC_000907.1.
DR   RefSeq; WP_005693269.1; NC_000907.1.
DR   AlphaFoldDB; P43747; -.
DR   SMR; P43747; -.
DR   STRING; 71421.HI_0923; -.
DR   PRIDE; P43747; -.
DR   EnsemblBacteria; AAC22583; AAC22583; HI_0923.
DR   KEGG; hin:HI_0923; -.
DR   PATRIC; fig|71421.8.peg.964; -.
DR   eggNOG; COG1466; Bacteria.
DR   HOGENOM; CLU_044694_0_2_6; -.
DR   OMA; RIPTGKP; -.
DR   PhylomeDB; P43747; -.
DR   BioCyc; HINF71421:G1GJ1-962-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR032780; DNA_pol3_delt_C.
DR   InterPro; IPR010372; DNA_pol3_delta_N.
DR   InterPro; IPR005790; DNA_polIII_delta.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF14840; DNA_pol3_delt_C; 1.
DR   Pfam; PF06144; DNA_pol3_delta; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01128; holA; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..344
FT                   /note="DNA polymerase III subunit delta"
FT                   /id="PRO_0000105506"
SQ   SEQUENCE   344 AA;  39845 MW;  5048DF5A42A97B5F CRC64;
     MNRIFPEQLN HHLAQGLARV YLLQGQDPLL LSETEDTICQ VANLQGFDEK NTIQVDSQTD
     WAQLIESCQS IGLFFSKQIL SLNLPENFTA LLQKNLQELI SVLHKDVLLI LQVAKLAKGI
     EKQTWFITLN QYEPNTILIN CQTPTVENLP RWVKNRTKAM GLDADNEAIQ QLCYSYENNL
     LALKQALQLL DLLYPDHKLN YNRVISVVEQ SSIFTPFQWI DALLVGKANR AKRILKGLQA
     EDVQPVILLR TLQRELFTLL ELTKPQQRIV TTEKLPIQQI KTEFDRLKIW QNRRPLFLSA
     IQRLTYQTLY EIIQELANIE RLAKQEFSDE VWIKLADLSV KICL