ID   HOLB_BUCAI              Reviewed;         326 AA.
AC   P57435;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=DNA polymerase III subunit delta';
DE            EC=2.7.7.7;
GN   Name=holB; OrderedLocusNames=BU354;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; BA000003; BAB13058.1; -; Genomic_DNA.
DR   RefSeq; NP_240172.1; NC_002528.1.
DR   RefSeq; WP_010896082.1; NC_002528.1.
DR   AlphaFoldDB; P57435; -.
DR   SMR; P57435; -.
DR   STRING; 107806.10039024; -.
DR   EnsemblBacteria; BAB13058; BAB13058; BAB13058.
DR   KEGG; buc:BU354; -.
DR   PATRIC; fig|107806.10.peg.367; -.
DR   eggNOG; COG0470; Bacteria.
DR   HOGENOM; CLU_006229_4_3_6; -.
DR   OMA; YSRCQVW; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..326
FT                   /note="DNA polymerase III subunit delta'"
FT                   /id="PRO_0000105510"
SQ   SEQUENCE   326 AA;  38453 MW;  BC0F123563B0062D CRC64;
     MKLYPWLIKP YNNIVQQYQK KKAHHAILIK TPRGIGVSLL IWFISKWLLC LKPIGLNSCD
     KCHGCKLMSA NNHPDWHNFT PEKNNLFSIE SVRIINEKIF TCSRQGGSKI IFLSDTGKLT
     ESAINAFLKT LEEPPRKTWF FLVNYKNLNS HSTLNSRCLI YKLFIPEEKK SLYWLKKETV
     KKNRSCLTAL RINQGSPLYA KKFINSNLWI DRINFYECLH DSFKKNNLLK ILPLITEKDS
     QVKIDWICFL LFDSIKFYFN ENDNLTNSDQ IELIQFFSYN YKNTILDTSI RTWLHCKYRL
     SNISGINCEL LLSEQLLIWE KILNFS