ID   3SP1_DENJA              Reviewed;          61 AA.
AC   P01413;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Toxin S5C1;
OS   Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8619;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=465532; DOI=10.1016/0005-2795(79)90101-6;
RA   Joubert F.J., Taljaard N.;
RT   "Some properties and the complete primary structures of two reduced and S-
RT   carboxymethylated polypeptides (S5C1 and S5C10) from Dendroaspis jamesoni
RT   kaimosae (Jameson's mamba) venom.";
RL   Biochim. Biophys. Acta 579:228-233(1979).
CC   -!- FUNCTION: Inhibits ADP-induced platelet aggregation and inhibits the
CC       binding of purified platelet fibrinogen receptor alpha-IIb/beta-3
CC       (ITGA2B/ITGB3) to immobilized fibrinogen.
CC       {ECO:0000250|UniProtKB:P28375}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:465532}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Antiplatelet toxin sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P01413; -.
DR   SMR; P01413; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Toxin.
FT   CHAIN           1..61
FT                   /note="Toxin S5C1"
FT                   /evidence="ECO:0000269|PubMed:465532"
FT                   /id="PRO_0000093658"
FT   MOTIF           45..47
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   DISULFID        3..22
FT                   /evidence="ECO:0000250|UniProtKB:P28375"
FT   DISULFID        16..39
FT                   /evidence="ECO:0000250|UniProtKB:P28375"
FT   DISULFID        41..53
FT                   /evidence="ECO:0000250|UniProtKB:P28375"
FT   DISULFID        54..59
FT                   /evidence="ECO:0000250|UniProtKB:P28375"
SQ   SEQUENCE   61 AA;  7024 MW;  34B25A68D48F7EAA CRC64;
     RICYNHLGTK PPTTECTQED SCYKNIWRNI TFDNIRRGCG CFTPRGDMPG PYCCESDKCN
     L