ID   HOLB_BUCBP              Reviewed;         336 AA.
AC   Q89AG8;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA polymerase III subunit delta';
DE            EC=2.7.7.7;
GN   Name=holB; OrderedLocusNames=bbp_324;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; AE016826; AAO27046.1; -; Genomic_DNA.
DR   RefSeq; WP_011091447.1; NC_004545.1.
DR   AlphaFoldDB; Q89AG8; -.
DR   SMR; Q89AG8; -.
DR   STRING; 224915.bbp_324; -.
DR   EnsemblBacteria; AAO27046; AAO27046; bbp_324.
DR   GeneID; 56470863; -.
DR   KEGG; bab:bbp_324; -.
DR   eggNOG; COG0470; Bacteria.
DR   HOGENOM; CLU_006229_4_3_6; -.
DR   OMA; INSANCC; -.
DR   OrthoDB; 1971388at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..336
FT                   /note="DNA polymerase III subunit delta'"
FT                   /id="PRO_0000105512"
SQ   SEQUENCE   336 AA;  39800 MW;  959F81090C4CEEAB CRC64;
     MNLYPWLQHS YKQIIYPHYI NKGHHSIILE SHKNIGITCL AKHISLWLLC QKKNKSIYHC
     KTCHSCQLMN SKNHPDWHYF GSNTCLSKNS SKTIGVNEVR NFTNTIFNSA QQGQNKIVYI
     PNIKKLTEFA INSLLKIIEE PPQNTYFLLI NYLPHKIITT LRSRCIIHNL YGPTKENRIE
     WLKEQNINTN QKIHMSMLYS NEISFISKCK HSLFFLYQER LNFFETLLTS FQEKNFLKML
     NVLNNKKCLD QIFIWICGII LDSIKWKHDI NTIIINTDQT KIIQILASNF SILSLDNSYK
     SWIYCYNNIK NIPGINIELL FVKQLLYWEE ILNIFN