ID   HOLB_HAEIN              Reviewed;         327 AA.
AC   P43748;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA polymerase III subunit delta';
DE            EC=2.7.7.7;
GN   Name=holB; OrderedLocusNames=HI_0455;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   SEQUENCE REVISION.
RA   White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; L42023; AAC22113.1; -; Genomic_DNA.
DR   RefSeq; NP_438616.1; NC_000907.1.
DR   RefSeq; WP_010868989.1; NC_000907.1.
DR   AlphaFoldDB; P43748; -.
DR   SMR; P43748; -.
DR   STRING; 71421.HI_0455; -.
DR   EnsemblBacteria; AAC22113; AAC22113; HI_0455.
DR   KEGG; hin:HI_0455; -.
DR   PATRIC; fig|71421.8.peg.475; -.
DR   eggNOG; COG0470; Bacteria.
DR   HOGENOM; CLU_006229_4_3_6; -.
DR   OMA; YSRCQVW; -.
DR   PhylomeDB; P43748; -.
DR   BioCyc; HINF71421:G1GJ1-471-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR004622; DNA_pol_HolB.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00678; holB; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..327
FT                   /note="DNA polymerase III subunit delta'"
FT                   /id="PRO_0000105514"
SQ   SEQUENCE   327 AA;  37039 MW;  CEE4D452E371A298 CRC64;
     MTALYPWLMP IYHQIAQTFD EGLGHHAVLI KADSGLGVES LFNALAQKIM CVAQGDKPCG
     QCHSCHLMQA HSHPDYHELS PINGKDIGVD QVRDINEMVA QHAQQNGNKV VYVQGAERLT
     EAAANALLKT LEEPRPNTYF LLQADSSASL LATIYSRCQV WNLSVPNEEI AFEWLKSKSA
     VENQEILTAL AMNLGRPLLA LETLQEGFIE QRKNFLRQFW VFYRRRSPLE LLPLFDKERY
     VQQVDWILAF LSDCLKHKLE IDSHRQVADL GRGIEQFSDE QTALGLLQAI KIMQKVRSDL
     LTINGVNVEL MLLDGLTRLV TEVFETQ