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HOLB_PSEAE
ID   HOLB_PSEAE              Reviewed;         328 AA.
AC   P52024;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   08-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA polymerase III subunit delta';
DE            EC=2.7.7.7;
GN   Name=holB; OrderedLocusNames=PA2961;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=8550441; DOI=10.1128/jb.178.1.46-53.1996;
RA   Alm R.A., Bodero A.J., Free P.D., Mattick J.S.;
RT   "Identification of a novel gene, pilZ, essential for type 4 fimbrial
RT   biogenesis in Pseudomonas aeruginosa.";
RL   J. Bacteriol. 178:46-53(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; L42622; AAA93518.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06349.1; -; Genomic_DNA.
DR   PIR; A59241; A59241.
DR   PIR; D83275; D83275.
DR   RefSeq; NP_251651.1; NC_002516.2.
DR   RefSeq; WP_003104126.1; NZ_QZGE01000009.1.
DR   AlphaFoldDB; P52024; -.
DR   SMR; P52024; -.
DR   STRING; 287.DR97_4978; -.
DR   PaxDb; P52024; -.
DR   PRIDE; P52024; -.
DR   EnsemblBacteria; AAG06349; AAG06349; PA2961.
DR   GeneID; 880379; -.
DR   KEGG; pae:PA2961; -.
DR   PATRIC; fig|208964.12.peg.3107; -.
DR   PseudoCAP; PA2961; -.
DR   HOGENOM; CLU_006229_4_3_6; -.
DR   InParanoid; P52024; -.
DR   OMA; DWFCDWA; -.
DR   PhylomeDB; P52024; -.
DR   BioCyc; PAER208964:G1FZ6-3013-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004622; DNA_pol_HolB.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00678; holB; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..328
FT                   /note="DNA polymerase III subunit delta'"
FT                   /id="PRO_0000105515"
FT   CONFLICT        16..30
FT                   /note="GGRAQHAHAYLLYGP -> RPRPARPRLSALAS (in Ref. 1;
FT                   AAA93518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        48..52
FT                   /note="CQRPA -> TRAC (in Ref. 1; AAA93518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        176..177
FT                   /note="RA -> PG (in Ref. 1; AAA93518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208..209
FT                   /note="VR -> AG (in Ref. 1; AAA93518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        238..251
FT                   /note="SVPLPLLFDWFCDW -> RVPIAIALRLVLRL (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        285..286
FT                   /note="QA -> HR (in Ref. 1; AAA93518)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        322
FT                   /note="A -> G (in Ref. 1; AAA93518)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   328 AA;  35746 MW;  55DAA4F223C1464D CRC64;
     MADIYPWQQA LWSQLGGRAQ HAHAYLLYGP AGIGKRALAE HWAAQLLCQR PAAAGACGEC
     KACQLLAAGT HPDYFVLEPE EAEKPIRVDQ VRDLVGFVVQ TAQLGGRKVV LLEPAEAMNV
     NAANALLKSL EEPSGDTVLL LISHQPSRLL PTIKSRCVQQ ACPLPGAAAS LEWLARALPD
     EPAEALEELL ALSGGSPLTA QRLHGQGVRE QRAQVVEGVK KLLKQQIAAS PLAESWNSVP
     LPLLFDWFCD WTLGILRYQL THDEEGLGLA DMRKVIQYLG DKSGQAKVLA MQDWLLQQRQ
     KVLNKANLNR VLLLEALLVQ WASLPGPG
 
 
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