ID   HOLB_YERPE              Reviewed;         340 AA.
AC   O69170; Q0WGH1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=DNA polymerase III subunit delta';
DE            EC=2.7.7.7;
GN   Name=holB; OrderedLocusNames=YPO1606, y1765, YP_2248;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-189.
RC   STRAIN=6/69C;
RX   PubMed=10491164; DOI=10.1046/j.1432-1327.1999.00691.x;
RA   Chenal-Francisque V., Tourneux L., Carniel E., Christova P.,
RA   Li de la Sierra I., Barzu O., Gilles A.-M.;
RT   "The highly similar TMP kinases of Yersinia pestis and Escherichia coli
RT   differ markedly in their AZTMP phosphorylating activity.";
RL   Eur. J. Biochem. 265:112-119(1999).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: The DNA polymerase holoenzyme is a complex that contains 10
CC       different types of subunits. These subunits are organized into 3
CC       functionally essential subassemblies: the pol III core, the beta
CC       sliding clamp processivity factor and the clamp-loading complex. The
CC       pol III core (subunits alpha,epsilon and theta) contains the polymerase
CC       and the 3'-5' exonuclease proofreading activities. The polymerase is
CC       tethered to the template via the sliding clamp processivity factor. The
CC       clamp-loading complex assembles the beta processivity factor onto the
CC       primer template and plays a central role in the organization and
CC       communication at the replication fork. This complex contains delta,
CC       delta', psi and chi, and copies of either or both of two different DnaX
CC       proteins, gamma and tau. The composition of the holoenzyme is,
CC       therefore: (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta',
CC       psi,chi-beta[4] (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM85333.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS62454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL20251.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85333.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS62454.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF065312; AAC18856.1; -; Genomic_DNA.
DR   PIR; AI0195; AI0195.
DR   RefSeq; WP_002213083.1; NZ_WUCM01000130.1.
DR   RefSeq; YP_002346617.1; NC_003143.1.
DR   AlphaFoldDB; O69170; -.
DR   SMR; O69170; -.
DR   STRING; 214092.YPO1606; -.
DR   PaxDb; O69170; -.
DR   DNASU; 1146712; -.
DR   EnsemblBacteria; AAM85333; AAM85333; y1765.
DR   EnsemblBacteria; AAS62454; AAS62454; YP_2248.
DR   GeneID; 57976965; -.
DR   KEGG; ype:YPO1606; -.
DR   KEGG; ypk:y1765; -.
DR   KEGG; ypm:YP_2248; -.
DR   PATRIC; fig|214092.21.peg.1949; -.
DR   eggNOG; COG0470; Bacteria.
DR   HOGENOM; CLU_006229_4_3_6; -.
DR   OMA; YSRCQVW; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR004622; DNA_pol_HolB.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00678; holB; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..340
FT                   /note="DNA polymerase III subunit delta'"
FT                   /id="PRO_0000105516"
FT   CONFLICT        137
FT                   /note="E -> Q (in Ref. 4; AAC18856)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   340 AA;  38114 MW;  C4F199180586C6C9 CRC64;
     MNWYPWLNAP YRQLVGQHST GRGHHALLLH SLPGNGEDAL IYALSRWLMC QQRQGEKSCG
     ECHSCRLMLA GNHPDWYVLT PEKGKSSIGV ELVRQLIDKL YSHAQQGGAK VVWLPHAEVL
     TDAAANALLK TLEEPPEKTY FLLDCHQPAS LLATLRSRCF YWYLACPDTA ICLQWLNLQW
     RKRQIPVEPV AMLAALKLSE GAPLAAERLL QPERWSIRSA LCSGLREALN RSDLLSLLPQ
     LNHDDAAERL QWLSSLLLDA LKWQQGAGEF AVNQDQLPLV QQLAHIAATP VLLQLAKQLA
     HCRHQLLSVV GVNRELLLTE QLLSWETALS TGTYSTLPSL