ID   HOLC_HAEIN              Reviewed;         144 AA.
AC   P43749;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA polymerase III subunit chi;
DE            EC=2.7.7.7;
GN   Name=holC; OrderedLocusNames=HI_1397;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-144.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7959067; DOI=10.1016/0378-1119(94)90861-3;
RA   Nwankwo D.O., Moran L.S., Slatko B.E., Waite-Rees P.A., Dorner L.F.,
RA   Benner J.S., Wilson G.G.;
RT   "Cloning, analysis and expression of the HindIII R-M-encoding genes.";
RL   Gene 150:75-80(1994).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC23044.1; -; Genomic_DNA.
DR   EMBL; L15391; AAA61957.1; -; Genomic_DNA.
DR   PIR; I64121; I64121.
DR   RefSeq; NP_439550.1; NC_000907.1.
DR   RefSeq; WP_005693964.1; NC_000907.1.
DR   AlphaFoldDB; P43749; -.
DR   SMR; P43749; -.
DR   STRING; 71421.HI_1397; -.
DR   EnsemblBacteria; AAC23044; AAC23044; HI_1397.
DR   KEGG; hin:HI_1397; -.
DR   PATRIC; fig|71421.8.peg.1457; -.
DR   eggNOG; COG2927; Bacteria.
DR   HOGENOM; CLU_131584_0_0_6; -.
DR   OMA; WQFEPSA; -.
DR   PhylomeDB; P43749; -.
DR   BioCyc; HINF71421:G1GJ1-1424-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0032298; P:positive regulation of DNA-templated DNA replication initiation; IBA:GO_Central.
DR   Gene3D; 3.40.50.10110; -; 1.
DR   InterPro; IPR007459; DNA_pol3_chi.
DR   InterPro; IPR036768; PolIII_chi_sf.
DR   PANTHER; PTHR38767; PTHR38767; 1.
DR   Pfam; PF04364; DNA_pol3_chi; 1.
DR   SUPFAM; SSF102400; SSF102400; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..144
FT                   /note="DNA polymerase III subunit chi"
FT                   /id="PRO_0000105518"
SQ   SEQUENCE   144 AA;  16636 MW;  A4571B90253C9D45 CRC64;
     MAKTAQFYIL TENCTLTVEE IACNLAASIW RSGKKVLISC ESEAQALEID ERLWQRDPNE
     FVPHNLSGEA TQYPTPIEIS WLGKRNLQRR DLLINLQQEI PDFSHSFTQI IDFVPKDDAL
     KTQARERYKQ LRLQGWNLST ENVG