ID   HOLC_PSEAE              Reviewed;         142 AA.
AC   O68823;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DNA polymerase III subunit chi;
DE            EC=2.7.7.7;
GN   Name=holC; OrderedLocusNames=PA3832;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FRD1;
RX   PubMed=9864319; DOI=10.1128/jb.181.1.107-116.1999;
RA   Woolwine S.C., Wozniak D.J.;
RT   "Identification of an Escherichia coli pepA homolog and its involvement in
RT   suppression of the algB phenotype in mucoid Pseudomonas aeruginosa.";
RL   J. Bacteriol. 181:107-116(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC       responsible for most of the replicative synthesis in bacteria. This DNA
CC       polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC       and theta chains) that associates with a tau subunit. This core
CC       dimerizes to form the POLIII' complex. PolIII' associates with the
CC       gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC       and with the beta chain to form the complete DNA polymerase III complex
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; AF054622; AAD04822.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG07219.1; -; Genomic_DNA.
DR   PIR; E83167; E83167.
DR   RefSeq; NP_252521.1; NC_002516.2.
DR   RefSeq; WP_003100593.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; O68823; -.
DR   SMR; O68823; -.
DR   STRING; 287.DR97_4034; -.
DR   PaxDb; O68823; -.
DR   PRIDE; O68823; -.
DR   DNASU; 879882; -.
DR   EnsemblBacteria; AAG07219; AAG07219; PA3832.
DR   GeneID; 879882; -.
DR   KEGG; pae:PA3832; -.
DR   PATRIC; fig|208964.12.peg.4012; -.
DR   PseudoCAP; PA3832; -.
DR   HOGENOM; CLU_131584_2_1_6; -.
DR   InParanoid; O68823; -.
DR   OMA; WQFEPSA; -.
DR   PhylomeDB; O68823; -.
DR   BioCyc; PAER208964:G1FZ6-3904-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0032298; P:positive regulation of DNA-templated DNA replication initiation; IBA:GO_Central.
DR   Gene3D; 3.40.50.10110; -; 1.
DR   InterPro; IPR007459; DNA_pol3_chi.
DR   InterPro; IPR036768; PolIII_chi_sf.
DR   PANTHER; PTHR38767; PTHR38767; 1.
DR   Pfam; PF04364; DNA_pol3_chi; 1.
DR   SUPFAM; SSF102400; SSF102400; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..142
FT                   /note="DNA polymerase III subunit chi"
FT                   /id="PRO_0000105519"
SQ   SEQUENCE   142 AA;  16141 MW;  18F6A2A37780E21C CRC64;
     MTRVDFYVIP SADPSARLQV ACRLAEKAWR QGMQVYLHCA DEAQRSELDG RLWSFRGEAF
     IPHSLAEEDA EAPVALGLGE PPGNHRDLLI NLTLEAPGFV PNFSRVAELV VEEPAIRQAA
     RDKFRFYREQ GYPLQDHRLP RI