ID   AOR_PYRAB               Reviewed;         607 AA.
AC   Q9V035; G8ZIC8;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Tungsten-containing aldehyde ferredoxin oxidoreductase;
DE            EC=1.2.7.5;
GN   Name=aor; OrderedLocusNames=PYRAB09630; ORFNames=PAB0647;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC         carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=W-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI:60537;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD)
CC       cofactor per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AOR/FOR family. {ECO:0000305}.
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DR   EMBL; AJ248286; CAB49871.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70369.1; -; Genomic_DNA.
DR   PIR; B75071; B75071.
DR   RefSeq; WP_010868080.1; NC_000868.1.
DR   AlphaFoldDB; Q9V035; -.
DR   SMR; Q9V035; -.
DR   STRING; 272844.PAB0647; -.
DR   EnsemblBacteria; CAB49871; CAB49871; PAB0647.
DR   GeneID; 1496313; -.
DR   KEGG; pab:PAB0647; -.
DR   PATRIC; fig|272844.11.peg.1015; -.
DR   eggNOG; arCOG00706; Archaea.
DR   HOGENOM; CLU_020364_1_0_2; -.
DR   OMA; IHIGQFR; -.
DR   OrthoDB; 9593at2157; -.
DR   PhylomeDB; Q9V035; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; -; 1.
DR   Gene3D; 1.10.599.10; -; 1.
DR   Gene3D; 3.60.9.10; -; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; SSF48310; 1.
DR   SUPFAM; SSF56228; SSF56228; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Tungsten.
FT   CHAIN           1..607
FT                   /note="Tungsten-containing aldehyde ferredoxin
FT                   oxidoreductase"
FT                   /id="PRO_0000064605"
SQ   SEQUENCE   607 AA;  67520 MW;  5CC3135C6E622505 CRC64;
     MFGYWGKILR VNLTDGTIKE ETFNEEFAKK WLGTRGFGIY FLLKEMDPKV DPFSPENKLI
     FATGPLTGTS APTGGRYMVI TKSPLTGYIA MANSGGYFGA ELKFAGWDAI IIEGKADHPV
     YLYIHDENVE IRDASKVWGK LVSETEKALK EEVGDKHVQI ASIGPAGENK VRFAAVMNNG
     HRAAGRGGVG AVMGSKNLKA IVVRGHKRVE VADKGKFMEV IREKIEKLKK DPVAGGGLPK
     YGTAVLVNII NEHGLYPTRN FQTGVFEYAY EQSGEAMAAK YLIRNKPCFA CPIGCGRVNY
     LPSIGETEGP EYESTWALGA NLGINDLASI IEANHFADEY GMDTISLGGT LATAMELYER
     GLIKQEDIGG ENEPPFRFGN TEVLHYWIHK IAKREGFGDI LAEGGYRLAE RFNGTEYFMG
     VKKQELPAYD PRGAEGHGLG YATNNRGGCH IKQYMISPEI LGYPYKMDPH DISDEKVKMV
     ILFQDLTALI DAAGLCLFTT FGLGADDYRD MLNAALGWDF STEDYLKIGE RIWNAERLFN
     LKAGLDPLKE DTLPKRLLEE PMPEGPNKGH VVRLKEMLPR YYKLRGWTED GRIPEEKLKE
     LGLEEFI