HOLD_HAEIN
ID HOLD_HAEIN Reviewed; 134 AA.
AC P43750;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=DNA polymerase III subunit psi;
DE EC=2.7.7.7;
GN Name=holD; OrderedLocusNames=HI_0011;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity. The exact
CC function of the psi subunit is unknown (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III complex
CC (By similarity). {ECO:0000250}.
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DR EMBL; L42023; AAC21689.1; -; Genomic_DNA.
DR PIR; E64042; E64042.
DR RefSeq; NP_438184.1; NC_000907.1.
DR RefSeq; WP_005663309.1; NC_000907.1.
DR AlphaFoldDB; P43750; -.
DR SMR; P43750; -.
DR STRING; 71421.HI_0011; -.
DR EnsemblBacteria; AAC21689; AAC21689; HI_0011.
DR KEGG; hin:HI_0011; -.
DR PATRIC; fig|71421.8.peg.11; -.
DR eggNOG; COG3050; Bacteria.
DR HOGENOM; CLU_132082_0_0_6; -.
DR OMA; QICAHEH; -.
DR PhylomeDB; P43750; -.
DR BioCyc; HINF71421:G1GJ1-11-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.10220; -; 1.
DR InterPro; IPR004615; DNA_pol_III_psi.
DR InterPro; IPR036654; DNA_pol_III_psi_sf.
DR InterPro; IPR018382; DNA_pol_III_psi_subgr.
DR Pfam; PF03603; DNA_III_psi; 1.
DR PIRSF; PIRSF029225; DNA_pol_III_psi; 1.
DR SUPFAM; SSF102220; SSF102220; 1.
DR TIGRFAMs; TIGR00664; DNA_III_psi; 1.
PE 3: Inferred from homology;
KW DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW Reference proteome; Transferase.
FT CHAIN 1..134
FT /note="DNA polymerase III subunit psi"
FT /id="PRO_0000105521"
SQ SEQUENCE 134 AA; 15718 MW; EFBFED319F5B8623 CRC64;
MNRRDLLLQE MGISQWELYR PEVLQGSVGI SVAENIRLIT VSDENISSSP LLADVLLSLN
LKKENCLCLN YDQIQHMECK QPIRYWLLSE NSDQIDRTLP FCKQAEQVYR SPSWQQFQSN
HQAKRALWQQ IQQP
