HOMEZ_HUMAN
ID HOMEZ_HUMAN Reviewed; 550 AA.
AC Q8IX15; A1L445; B4DZ80; F8WCA3; Q6P049; Q86XB6; Q9P2A5;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Homeobox and leucine zipper protein Homez;
DE AltName: Full=Homeodomain leucine zipper-containing factor;
GN Name=HOMEZ; Synonyms=KIAA1443;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE
RP SPLICING, INTERACTION WITH HOXC8, AND TISSUE SPECIFICITY.
RX PubMed=12925734; DOI=10.1073/pnas.1834010100;
RA Bayarsaihan D., Enkhmandakh B., Makeyev A., Greally J.M., Leckman J.F.,
RA Ruddle F.H.;
RT "Homez, a homeobox leucine zipper gene specific to the vertebrate
RT lineage.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10358-10363(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-550 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-451, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351 AND THR-451, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-182, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA Vertegaal A.C.;
RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL Cell Rep. 10:1778-1791(2015).
RN [10]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-182; LYS-200 AND LYS-202, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [11]
RP STRUCTURE BY NMR OF 361-423 AND 453-509.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the homeobox domains of human homeodomain leucine
RT zipper-encoding gene (HOMEZ).";
RL Submitted (FEB-2007) to the PDB data bank.
CC -!- FUNCTION: May function as a transcriptional regulator.
CC -!- SUBUNIT: Homodimer or heterodimer (Potential). Interacts with HOXC8.
CC {ECO:0000269|PubMed:12925734, ECO:0000305}.
CC -!- INTERACTION:
CC Q8IX15; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=4; IntAct=EBI-10742083, EBI-25492395;
CC Q8IX15-3; Q8WTP8: AEN; NbExp=3; IntAct=EBI-10172004, EBI-8637627;
CC Q8IX15-3; Q8N2Z9: CENPS; NbExp=3; IntAct=EBI-10172004, EBI-5529649;
CC Q8IX15-3; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-10172004, EBI-745369;
CC Q8IX15-3; Q9H147: DNTTIP1; NbExp=3; IntAct=EBI-10172004, EBI-2795449;
CC Q8IX15-3; Q9UH73: EBF1; NbExp=3; IntAct=EBI-10172004, EBI-765426;
CC Q8IX15-3; O60573: EIF4E2; NbExp=3; IntAct=EBI-10172004, EBI-398610;
CC Q8IX15-3; Q14241: ELOA; NbExp=3; IntAct=EBI-10172004, EBI-742350;
CC Q8IX15-3; P62993: GRB2; NbExp=3; IntAct=EBI-10172004, EBI-401755;
CC Q8IX15-3; P52292: KPNA2; NbExp=3; IntAct=EBI-10172004, EBI-349938;
CC Q8IX15-3; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10172004, EBI-739832;
CC Q8IX15-3; A1L1C6: LRRC7; NbExp=3; IntAct=EBI-10172004, EBI-10171988;
CC Q8IX15-3; Q15013: MAD2L1BP; NbExp=3; IntAct=EBI-10172004, EBI-712181;
CC Q8IX15-3; Q9BUE0: MED18; NbExp=3; IntAct=EBI-10172004, EBI-394640;
CC Q8IX15-3; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-10172004, EBI-5453723;
CC Q8IX15-3; O43639: NCK2; NbExp=3; IntAct=EBI-10172004, EBI-713635;
CC Q8IX15-3; Q13526: PIN1; NbExp=3; IntAct=EBI-10172004, EBI-714158;
CC Q8IX15-3; Q13131: PRKAA1; NbExp=3; IntAct=EBI-10172004, EBI-1181405;
CC Q8IX15-3; P54646: PRKAA2; NbExp=3; IntAct=EBI-10172004, EBI-1383852;
CC Q8IX15-3; Q14498-3: RBM39; NbExp=3; IntAct=EBI-10172004, EBI-6654703;
CC Q8IX15-3; O76064: RNF8; NbExp=3; IntAct=EBI-10172004, EBI-373337;
CC Q8IX15-3; Q92834: RPGR; NbExp=3; IntAct=EBI-10172004, EBI-6558417;
CC Q8IX15-3; Q92834-6: RPGR; NbExp=3; IntAct=EBI-10172004, EBI-16431517;
CC Q8IX15-3; P32969: RPL9P9; NbExp=3; IntAct=EBI-10172004, EBI-358122;
CC Q8IX15-3; O00560: SDCBP; NbExp=3; IntAct=EBI-10172004, EBI-727004;
CC Q8IX15-3; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-10172004, EBI-10225873;
CC Q8IX15-3; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-10172004, EBI-8463848;
CC Q8IX15-3; P08579: SNRPB2; NbExp=3; IntAct=EBI-10172004, EBI-1053651;
CC Q8IX15-3; P61956: SUMO2; NbExp=3; IntAct=EBI-10172004, EBI-473220;
CC Q8IX15-3; Q15561: TEAD4; NbExp=3; IntAct=EBI-10172004, EBI-747736;
CC Q8IX15-3; Q08117: TLE5; NbExp=3; IntAct=EBI-10172004, EBI-717810;
CC Q8IX15-3; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-10172004, EBI-3650647;
CC Q8IX15-3; O95365: ZBTB7A; NbExp=3; IntAct=EBI-10172004, EBI-2795384;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:12925734}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IX15-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IX15-3; Sequence=VSP_054303;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Strongly expressed in adult testis and
CC kidney as well as fetal lung and kidney. {ECO:0000269|PubMed:12925734}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-25 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN76991.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA92681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF463523; AAN76991.1; ALT_INIT; mRNA.
DR EMBL; AB037864; BAA92681.1; ALT_INIT; mRNA.
DR EMBL; AK302788; BAG63992.1; -; mRNA.
DR EMBL; AL049829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130392; AAI30393.1; -; mRNA.
DR CCDS; CCDS45085.1; -. [Q8IX15-1]
DR RefSeq; NP_065885.2; NM_020834.2. [Q8IX15-1]
DR PDB; 2ECC; NMR; -; A=361-423.
DR PDB; 2YS9; NMR; -; A=453-509.
DR PDBsum; 2ECC; -.
DR PDBsum; 2YS9; -.
DR AlphaFoldDB; Q8IX15; -.
DR BMRB; Q8IX15; -.
DR SMR; Q8IX15; -.
DR BioGRID; 121645; 139.
DR IntAct; Q8IX15; 56.
DR MINT; Q8IX15; -.
DR STRING; 9606.ENSP00000350049; -.
DR iPTMnet; Q8IX15; -.
DR PhosphoSitePlus; Q8IX15; -.
DR BioMuta; HOMEZ; -.
DR DMDM; 317373364; -.
DR EPD; Q8IX15; -.
DR jPOST; Q8IX15; -.
DR MassIVE; Q8IX15; -.
DR MaxQB; Q8IX15; -.
DR PaxDb; Q8IX15; -.
DR PeptideAtlas; Q8IX15; -.
DR PRIDE; Q8IX15; -.
DR ProteomicsDB; 70963; -. [Q8IX15-1]
DR Antibodypedia; 22427; 151 antibodies from 26 providers.
DR DNASU; 57594; -.
DR Ensembl; ENST00000357460.7; ENSP00000350049.4; ENSG00000215271.9. [Q8IX15-1]
DR Ensembl; ENST00000561013.2; ENSP00000453979.1; ENSG00000215271.9. [Q8IX15-3]
DR GeneID; 57594; -.
DR KEGG; hsa:57594; -.
DR MANE-Select; ENST00000357460.7; ENSP00000350049.4; NM_020834.3; NP_065885.2.
DR UCSC; uc001wja.3; human. [Q8IX15-1]
DR CTD; 57594; -.
DR DisGeNET; 57594; -.
DR GeneCards; HOMEZ; -.
DR HGNC; HGNC:20164; HOMEZ.
DR HPA; ENSG00000215271; Tissue enhanced (testis).
DR MIM; 608119; gene.
DR neXtProt; NX_Q8IX15; -.
DR OpenTargets; ENSG00000215271; -.
DR PharmGKB; PA162391555; -.
DR VEuPathDB; HostDB:ENSG00000215271; -.
DR eggNOG; KOG3986; Eukaryota.
DR GeneTree; ENSGT00950000182893; -.
DR HOGENOM; CLU_032878_0_0_1; -.
DR InParanoid; Q8IX15; -.
DR OMA; ERYWATH; -.
DR OrthoDB; 518562at2759; -.
DR PhylomeDB; Q8IX15; -.
DR TreeFam; TF333363; -.
DR PathwayCommons; Q8IX15; -.
DR SignaLink; Q8IX15; -.
DR BioGRID-ORCS; 57594; 21 hits in 1098 CRISPR screens.
DR ChiTaRS; HOMEZ; human.
DR EvolutionaryTrace; Q8IX15; -.
DR GenomeRNAi; 57594; -.
DR Pharos; Q8IX15; Tdark.
DR PRO; PR:Q8IX15; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8IX15; protein.
DR Bgee; ENSG00000215271; Expressed in left testis and 98 other tissues.
DR ExpressionAtlas; Q8IX15; baseline and differential.
DR Genevisible; Q8IX15; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF11569; Homez; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; DNA-binding; Homeobox; Isopeptide bond;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..550
FT /note="Homeobox and leucine zipper protein Homez"
FT /id="PRO_0000049135"
FT DNA_BIND 55..114
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 355..415
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 451..510
FT /note="Homeobox 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 358..363
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 223..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 451
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:23186163"
FT CROSSLNK 182
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25772364,
FT ECO:0007744|PubMed:28112733"
FT CROSSLNK 200
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 202
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..13
FT /note="MVRGWEPPPGLDC -> MLKSRISMRSRHPRR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054303"
FT VARIANT 278
FT /note="A -> T (in dbSNP:rs10131813)"
FT /id="VAR_055956"
FT CONFLICT 302
FT /note="A -> T (in Ref. 5; AAI30393)"
FT /evidence="ECO:0000305"
FT CONFLICT 529
FT /note="Missing (in Ref. 1; AAN76991, 2; BAA92681 and 5;
FT AAI30393)"
FT /evidence="ECO:0000305"
FT CONFLICT 538
FT /note="D -> E (in Ref. 5; AAI30393)"
FT /evidence="ECO:0000305"
FT CONFLICT 538
FT /note="Missing (in Ref. 3; BAG63992)"
FT /evidence="ECO:0000305"
FT HELIX 365..377
FT /evidence="ECO:0007829|PDB:2ECC"
FT HELIX 383..392
FT /evidence="ECO:0007829|PDB:2ECC"
FT HELIX 397..413
FT /evidence="ECO:0007829|PDB:2ECC"
FT HELIX 464..472
FT /evidence="ECO:0007829|PDB:2YS9"
FT HELIX 480..487
FT /evidence="ECO:0007829|PDB:2YS9"
FT HELIX 492..502
FT /evidence="ECO:0007829|PDB:2YS9"
SQ SEQUENCE 550 AA; 61240 MW; A7DDF6DD56D8BDF0 CRC64;
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE LQLVWTQAAQ
TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK TWFMAQRLRC GISWSSEEIE
ETRARVVYRR DQLHFKSLLS FTHHAGRPPE EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG
LKVEPEEPSQ MPPLPQSHQK LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS
HGIGTASWNH STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL SPDMQRQRKT
KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI IQWFGDTRYA LKHGQLKWFR
DNAVPGAPSF QDPAIPTPPP STRSLNERAE TPPLPIPPPP PDIQPLERYW AAHQQLRETD
IPQLSQASRL STQQVLDWFD SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD
DDDDDVIIQD
