HOMEZ_RAT
ID HOMEZ_RAT Reviewed; 513 AA.
AC Q8K3E9;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Homeobox and leucine zipper protein Homez;
DE AltName: Full=Homeodomain leucine zipper-containing factor;
GN Name=Homez;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=12925734; DOI=10.1073/pnas.1834010100;
RA Bayarsaihan D., Enkhmandakh B., Makeyev A., Greally J.M., Leckman J.F.,
RA Ruddle F.H.;
RT "Homez, a homeobox leucine zipper gene specific to the vertebrate
RT lineage.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:10358-10363(2003).
CC -!- FUNCTION: May function as a transcriptional regulator.
CC -!- SUBUNIT: Homodimer or heterodimer (Potential). Interacts with HOXC8 (By
CC similarity). {ECO:0000250, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K3E9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K3E9-2; Sequence=VSP_009134;
CC -!- MISCELLANEOUS: [Isoform 2]: May result from the retention of an intron.
CC {ECO:0000305}.
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DR EMBL; AY126016; AAM94347.1; -; mRNA.
DR RefSeq; XP_008768885.2; XM_008770663.2. [Q8K3E9-2]
DR AlphaFoldDB; Q8K3E9; -.
DR BMRB; Q8K3E9; -.
DR SMR; Q8K3E9; -.
DR STRING; 10116.ENSRNOP00000019979; -.
DR iPTMnet; Q8K3E9; -.
DR PhosphoSitePlus; Q8K3E9; -.
DR PaxDb; Q8K3E9; -.
DR PRIDE; Q8K3E9; -.
DR Ensembl; ENSRNOT00000019979; ENSRNOP00000019979; ENSRNOG00000014887. [Q8K3E9-2]
DR Ensembl; ENSRNOT00000097673; ENSRNOP00000087732; ENSRNOG00000014887. [Q8K3E9-1]
DR Ensembl; ENSRNOT00000118629; ENSRNOP00000082728; ENSRNOG00000014887. [Q8K3E9-1]
DR GeneID; 260325; -.
DR UCSC; RGD:628904; rat. [Q8K3E9-1]
DR CTD; 57594; -.
DR RGD; 628904; Homez.
DR eggNOG; KOG3986; Eukaryota.
DR GeneTree; ENSGT00950000182893; -.
DR InParanoid; Q8K3E9; -.
DR PRO; PR:Q8K3E9; -.
DR Proteomes; UP000002494; Chromosome 15.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR Pfam; PF11569; Homez; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..513
FT /note="Homeobox and leucine zipper protein Homez"
FT /id="PRO_0000049137"
FT DNA_BIND 31..90
FT /note="Homeobox 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 324..384
FT /note="Homeobox 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT DNA_BIND 418..477
FT /note="Homeobox 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 200..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 327..332
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 242..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IX15"
FT MOD_RES 418
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IX15"
FT CROSSLNK 156
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8IX15"
FT CROSSLNK 174
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8IX15"
FT CROSSLNK 176
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8IX15"
FT VAR_SEQ 496..513
FT /note="EEEEEEEEEEDDDVIIRD -> SVLWTEGPWSSN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12925734"
FT /id="VSP_009134"
SQ SEQUENCE 513 AA; 57677 MW; DD0CE477E78F5172 CRC64;
MSPNKDSSSL NSSGAGLVCL PPVSEELQLV WTQAVQTSEL DGNEHLLQAF SYFPYPSLAD
IALLCLRHGL QMEKVKTWFM AQRLRCGISW SSEEIEETRA RVVYHRDQLL FKSLLSFTHH
AVRPPQEMPP VTPPEQVALG LRPLALSEPT QMKGLKVEPE EPFQVSQLPL NHQKVKEPLM
MGSRTLNHQS DCQDLQISGL SKEQAGGGPD QSCGGGTASW NHSIAVHQPD KSPLISLLDN
SCKEESEPSG TPPSSSASSP FQVLANGTTA TPKPLQPLGY IPQSFSPSEQ ALSPQVEPLW
SQRLRNNSVP SRVGPTEYLS PDMQHQRKTK RKTKEQLAIL KSFFLQCQWA RREDYHKLEQ
ITGLPRPEII QWFGDTRYAL KHGQLKWFRD NAVLGTPSFQ DPAISTSSTR SLKEWAKTPP
LPAPPPPPDI RPLERYWAAH QQLQEADILK LSQASRLSTQ QVLDWFDSRL PKPAEVVVCL
DEEEEEEDEE LPEDGEEEEE EEEEEDDDVI IRD
