ID   HOOK1_CHICK             Reviewed;         718 AA.
AC   Q5ZJ27;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein Hook homolog 1;
GN   Name=HOOK1; ORFNames=RCJMB04_21h9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hook family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720607; CAG32266.1; -; mRNA.
DR   RefSeq; NP_001006542.1; NM_001006542.1.
DR   AlphaFoldDB; Q5ZJ27; -.
DR   SMR; Q5ZJ27; -.
DR   STRING; 9031.ENSGALP00000017678; -.
DR   PaxDb; Q5ZJ27; -.
DR   GeneID; 424675; -.
DR   KEGG; gga:424675; -.
DR   CTD; 51361; -.
DR   VEuPathDB; HostDB:geneid_424675; -.
DR   eggNOG; ENOG502QQM8; Eukaryota.
DR   InParanoid; Q5ZJ27; -.
DR   OrthoDB; 398210at2759; -.
DR   PhylomeDB; Q5ZJ27; -.
DR   PRO; PR:Q5ZJ27; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   Pfam; PF05622; HOOK; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   PROSITE; PS50021; CH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..718
FT                   /note="Protein Hook homolog 1"
FT                   /id="PRO_0000379053"
FT   DOMAIN          8..124
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   COILED          164..428
FT                   /evidence="ECO:0000255"
FT   COILED          473..652
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   718 AA;  82980 MW;  D6C9CBE903689C60 CRC64;
     MEGKAADPLL CDSLILWLQT FNTAAPCRNV QDLTNGVAMA QVLHQIDVAW FDASWLNRIK
     EDVGDNWRIK SSNLKKILQG IMDYYHEFLD QQISEELIPD LNKISENSDP TELGRLMQLI
     LGCAVNCERK QEHIQNIMTL EESVQHVVMT AIQELMSKEA MGPSASDVSS EMEQQLKKAL
     EDLQEAIAEK EELAQRCQEL DLQVAALQDE KNSLVSENEI LNDRLEQLDD SLDDPNTVVA
     KKYFHAQLQL EQLQEENFRL EAAKDDYRVH CEDLEKQLIE LQHRNNELTS LAEESRALKD
     ENDILRAAAD KASKLESTVE VYRKKLQDLN DFRRQVKSLQ ETNMMYMHNT VSLEDELREA
     NAARAQLETY KRQVQELHNK LSEESKRADK LAFEMKRLEE KHEALVKEKE RLVIQCDALK
     ETNEELRYSQ MQQDHLSRTD ASRIKSHDNL AAELLPVEYR EMFIQLQHEN KMLLLQQEGS
     ENERIMELQK QLEQKQWTVN ELGTEKRLNK ERIGELQQQI EDLQKTLQEQ GSKTEGSSNL
     KQKLAAHMEK LSEVHDELQK KEAALAELQP DVSQNPQKIG ELEAALRKKD EDMKAMEERY
     KMYLEKARNV IKTLDPKLNP ASAEIMLLRK QITERDKKIE ALEAEYKLAK LRDYEENLIV
     TAWYNKSLTL QKLGMEARLL GSGGACRDGP GRSFLAQQRH VTNTRRNLPV KVPSATSD