ID   HOOK1_DANRE             Reviewed;         715 AA.
AC   Q5TZ80; B3DI93;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein Hook homolog 1;
GN   Name=hook1; ORFNames=si:dkey-183n20.14;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hook family. {ECO:0000305}.
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DR   EMBL; BX322665; CAH69008.1; -; Genomic_DNA.
DR   EMBL; BC163044; AAI63044.1; -; mRNA.
DR   RefSeq; NP_001038663.1; NM_001045198.1.
DR   AlphaFoldDB; Q5TZ80; -.
DR   SMR; Q5TZ80; -.
DR   STRING; 7955.ENSDARP00000063051; -.
DR   PaxDb; Q5TZ80; -.
DR   PRIDE; Q5TZ80; -.
DR   Ensembl; ENSDART00000063052; ENSDARP00000063051; ENSDARG00000042946.
DR   GeneID; 570393; -.
DR   KEGG; dre:570393; -.
DR   CTD; 51361; -.
DR   ZFIN; ZDB-GENE-041001-159; hook1.
DR   eggNOG; ENOG502QQM8; Eukaryota.
DR   GeneTree; ENSGT00940000159251; -.
DR   HOGENOM; CLU_011214_1_0_1; -.
DR   InParanoid; Q5TZ80; -.
DR   OMA; LRYSQMQ; -.
DR   OrthoDB; 398210at2759; -.
DR   PhylomeDB; Q5TZ80; -.
DR   TreeFam; TF320231; -.
DR   PRO; PR:Q5TZ80; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000042946; Expressed in retina and 18 other tissues.
DR   ExpressionAtlas; Q5TZ80; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   Pfam; PF05622; HOOK; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   PROSITE; PS50021; CH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..715
FT                   /note="Protein Hook homolog 1"
FT                   /id="PRO_0000379054"
FT   DOMAIN          6..122
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   COILED          167..434
FT                   /evidence="ECO:0000255"
FT   COILED          463..656
FT                   /evidence="ECO:0000255"
FT   CONFLICT        411
FT                   /note="I -> F (in Ref. 2; AAI63044)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        605
FT                   /note="A -> P (in Ref. 2; AAI63044)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   715 AA;  83115 MW;  DDA952C364E54C30 CRC64;
     MDLKKTVLCE SLIIWLQTFK TAAPCKTVED LTSGAAMSQA LHQIDPSWFS ESWLARIKED
     VGDNVRLKMN NLKKILQMIV DYYNEVLAQQ MSDFPLPDLM RVVEQSDQVE LGRLLQLILG
     CAVKCDRKQE YIQIIMTLEE SVQHVVMTAI QELMSRESVS QLGAEPAGDT EQQLKKALED
     LTEVMAEKEE LAQRCQELDM QVTVLQEERN SLLAENDLLT DRSSQLETFD DPSTPSGRKH
     SQLQFQLEQL QEENFRLEAA KDDYRIHCEE LEKQLVELQH RNDELTSLAE ESRSLKDELD
     ILRSCSDRAV KLEASVETYR KKLEDLSDLR RQMKALEEKN MTYMHNTVSL EEELRKANAA
     RAQLETYKRQ VQELHKKLSD ESRRADNLVF EMKKLQEKYD ALVKERERIS IERDTLRETN
     EELRCTQAQQ DQLLLAGKYQ TGSPSHDNLA AEMLPIEYRE KFIRLQHENK MLRLQQEESE
     KQRITELQQQ LEEARRGRSQ LDTDNRLNRE RISELQQQVE DLQKALQTQG AKPDDSHLKR
     KLDAHMVQLN EAQDEIMKKK ELLEDLQPDA TQTSVKMDEL MAALKKKDED MRAMEDRYKM
     YLEKARDVIR ALDPKLNPAS AEIQSLKVQL SDKDKKIIAL ERECEQAKLR EYEEKLIVTA
     WYNKSLNFQK MAIESRLSGR ANSLVPPGQS FLAQQRQVTN ARRTMSINVP ASSSK