HOOK2_XENLA
ID HOOK2_XENLA Reviewed; 721 AA.
AC Q6NRB0;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Protein Hook homolog 2;
GN Name=hook2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function to promote vesicle trafficking and/or fusion.
CC May contribute to the establishment and maintenance of centrosome
CC function (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm,
CC cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the hook family. {ECO:0000305}.
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DR EMBL; BC070852; AAH70852.1; -; mRNA.
DR RefSeq; NP_001084809.1; NM_001091340.1.
DR AlphaFoldDB; Q6NRB0; -.
DR SMR; Q6NRB0; -.
DR IntAct; Q6NRB0; 1.
DR PRIDE; Q6NRB0; -.
DR DNASU; 431850; -.
DR GeneID; 431850; -.
DR KEGG; xla:431850; -.
DR CTD; 431850; -.
DR Xenbase; XB-GENE-991663; hook2.L.
DR OrthoDB; 398210at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 431850; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR PROSITE; PS50021; CH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..721
FT /note="Protein Hook homolog 2"
FT /id="PRO_0000379055"
FT DOMAIN 7..123
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 696..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 181..425
FT /evidence="ECO:0000255"
FT COILED 484..659
FT /evidence="ECO:0000255"
SQ SEQUENCE 721 AA; 84506 MW; 85B6FB24E3819005 CRC64;
MSSKRKVELC DSLLTWMQTF QVSGPCSSYE DLTGGVAIAQ VLNRIDPSWF NEAWLVRVKK
DTTENWRLKV SNLKRILQSV LEYYQDVLGH PVSDDHIPDV ALIGEFSNDT ELRKMVQLVL
GCAISCDKKE EHIQQIMTLG ESVQQAVMES IQELLSKAPS DAVTSESFIN YDSQSRKYYF
LSEDNDEKNE ILQRCHDLEQ QVSLLMEEKK NMMGENRTLK EQQEQSGMGT PQLFNKKLLL
LQSQIEQLQE ENYRLESSRD DYRQRCQELD RDVQELQQRN QDLTGLAHES QALRDEMDVL
RHSSDRVGKL ESLVDSYKKK LEDLGDLRRQ VKLLEERNTM YMQRTFQLEE DLHKANASRG
QVESLSRQVQ ELHKKHSTES LRAEKWQFEF QTLKEKFEAL QKERERLIAE RDSLRETNDE
LRCSHLQQTC LGQADLLLSG SSPPLENLAA EIVPAELRET VIRLQQENKM LCAQEASYHE
RLCDLQNFLE ESNRSKNRLE SESRLQQQQI KGLKAQVEEL QKQLREQGNR AEDSSQLKRK
LEEHLEMLHD AHSELQKKRE YIETLEPKAD LNMSRKVDEL QQILHQKEED MRAMEERYKR
YVDKARTVIK SLDPKQQNYI PPEIQALKNQ LQEKDTRIRH LETDYEKTKV QRDQEEKLII
SAWYNMGMAL HQKSTDEKTQ PPNGAQSFLA QQRLATNARR GQISRSHTLL PRYTDKRQSL
S