ID   HOOK3_BOVIN             Reviewed;          12 AA.
AC   P60316;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 1.
DT   02-JUN-2021, entry version 43.
DE   RecName: Full=Protein Hook homolog 3;
DE   Flags: Fragment;
GN   Name=HOOK3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE, AND INTERACTION WITH SPIC (MICROBIAL INFECTION).
RX   PubMed=12950921; DOI=10.1046/j.1365-2958.2003.03668.x;
RA   Shotland Y., Kraemer H., Groisman E.A.;
RT   "The Salmonella SpiC protein targets the mammalian Hook3 protein function
RT   to alter cellular trafficking.";
RL   Mol. Microbiol. 49:1565-1576(2003).
CC   -!- FUNCTION: Probably serves as a target for the spiC protein from
CC       Salmonella typhimurium, which inactivates it, leading to a strong
CC       alteration in cellular trafficking (By similarity). Component of the
CC       FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to
CC       promote vesicle trafficking and/or fusion via the homotypic vesicular
CC       protein sorting complex (the HOPS complex). May regulate clearance of
CC       endocytosed receptors such as MSR1. Participates in defining the
CC       architecture and localization of the Golgi complex. Acts as an adapter
CC       protein linking the dynein motor complex to various cargos and converts
CC       dynein from a non-processive to a highly processive motor in the
CC       presence of dynactin. Facilitates the interaction between dynein and
CC       dynactin and activates dynein processivity (the ability to move along a
CC       microtubule for a long distance without falling off the track) (By
CC       similarity). FHF complex promotes the distribution of AP-4 complex to
CC       the perinuclear area of the cell (By similarity).
CC       {ECO:0000250|UniProtKB:Q86VS8, ECO:0000250|UniProtKB:Q8BUK6}.
CC   -!- FUNCTION: (Microbial infection) Serves as a target for the spiC protein
CC       from Salmonella typhimurium, which inactivates it, leading to a strong
CC       alteration in cellular trafficking. {ECO:0000269|PubMed:12950921}.
CC   -!- SUBUNIT: Self-associates. Component of the FTS/Hook/FHIP complex (FHF
CC       complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the
CC       Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly
CC       with AKTIP/FTS, HOOK1 and HOOK2 (By similarity). Associates with
CC       several subunits of the homotypic vesicular sorting complex (the HOPS
CC       complex) including VPS16 and VPS41; these interactions may be indirect.
CC       Interacts with MSR1, and this association is stimulated by ligand
CC       binding to MSR1. Interacts with microtubules. Interacts with dynein
CC       intermediate chain and dynactin (DCTN1) (By similarity). Interacts with
CC       CCDC181 (By similarity). Interacts with LRGUK (By similarity).
CC       {ECO:0000250|UniProtKB:Q86VS8, ECO:0000250|UniProtKB:Q8BUK6}.
CC   -!- SUBUNIT: (Microbial infection) Interacts with Salmonella typhimurium
CC       spiC. {ECO:0000269|PubMed:12950921}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q86VS8}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q86VS8}. Note=Enriched at the cis-face of the
CC       Golgi complex. Localizes to microtubule asters in prophase (By
CC       similarity). Localizes to the manchette in elongating spermatids (By
CC       similarity). {ECO:0000250|UniProtKB:Q86VS8,
CC       ECO:0000250|UniProtKB:Q8BUK6}.
CC   -!- SIMILARITY: Belongs to the hook family. {ECO:0000305}.
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DR   OrthoDB; 398210at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0070695; C:FHF complex; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0034452; F:dynactin binding; ISS:UniProtKB.
DR   GO; GO:0045505; F:dynein intermediate chain binding; ISS:UniProtKB.
DR   GO; GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
DR   GO; GO:0007032; P:endosome organization; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Direct protein sequencing; Golgi apparatus;
KW   Microtubule; Protein transport; Reference proteome; Transport.
FT   CHAIN           <1..>12
FT                   /note="Protein Hook homolog 3"
FT                   /id="PRO_0000219196"
FT   NON_TER         1
FT   NON_TER         12
SQ   SEQUENCE   12 AA;  1417 MW;  04CE92493BB73404 CRC64;
     VELQNRLSDE SQ