ID   HOOK_ANOGA              Reviewed;         690 AA.
AC   Q7PWT9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 4.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Protein hook;
GN   Name=hook {ECO:0000250|UniProtKB:Q24185};
GN   Synonyms=hk {ECO:0000250|UniProtKB:Q24185}; ORFNames=AGAP008854;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Involved in endocytic trafficking. Probably acts as a
CC       cytoskeletal linker protein that tethers endosome vesicles to the
CC       cytoskeleton. {ECO:0000250|UniProtKB:Q24185}.
CC   -!- SUBUNIT: Homodimer. Interacts with microtubules via its N-terminus.
CC       {ECO:0000250|UniProtKB:Q24185}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q24185}. Endosome
CC       {ECO:0000250|UniProtKB:Q24185}.
CC   -!- DOMAIN: The coiled coil domain mediates homodimerization.
CC       {ECO:0000250|UniProtKB:Q24185}.
CC   -!- SIMILARITY: Belongs to the hook family. {ECO:0000305}.
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DR   EMBL; AAAB01008984; EAA14793.4; -; Genomic_DNA.
DR   RefSeq; XP_319596.4; XM_319596.4.
DR   AlphaFoldDB; Q7PWT9; -.
DR   SMR; Q7PWT9; -.
DR   STRING; 7165.AGAP008854-PA; -.
DR   PaxDb; Q7PWT9; -.
DR   GeneID; 1279821; -.
DR   KEGG; aga:AgaP_AGAP008854; -.
DR   CTD; 1279821; -.
DR   VEuPathDB; VectorBase:AGAP008854; -.
DR   eggNOG; ENOG502QQM8; Eukaryota.
DR   HOGENOM; CLU_011214_1_0_1; -.
DR   InParanoid; Q7PWT9; -.
DR   OMA; LEFNNHA; -.
DR   OrthoDB; 398210at2759; -.
DR   PhylomeDB; Q7PWT9; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; ISS:UniProtKB.
DR   GO; GO:0006897; P:endocytosis; ISS:UniProtKB.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   InterPro; IPR038077; Troponin_sf.
DR   Pfam; PF05622; HOOK; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   SUPFAM; SSF90250; SSF90250; 1.
DR   PROSITE; PS50021; CH; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Endocytosis; Endosome; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..690
FT                   /note="Protein hook"
FT                   /id="PRO_0000379060"
FT   DOMAIN          6..122
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   COILED          134..515
FT                   /evidence="ECO:0000255"
FT   COILED          546..577
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   690 AA;  77381 MW;  FBBC698611AF0169 CRC64;
     MENDKMEIYE SLIRWLSELN LSAPHGTVQE LSDGAALAQA LNQIAPEVFT DSWLSKIKSD
     VGANWRLKVS NLRKIIEGIY VYYQDELSLN LSEELRPDAL KIAEKGDPHE LGRLLQLILG
     CAVNCLEKQK YITQIMELEE SLQRNIMAAL QDIEYIWQGA SPSRNSINTA ATSLDVKTLQ
     EDRDTLAQKC HETNKKMLGL IEEKAALQQE IVKLQAIVGR YENPNLIGDD GTSLGPIQLG
     SSRYNDLRKL VDSLKDELLQ AETARDDLKM KSMIQEKEIG ELQVKIDELH AATAEIAQLK
     DEIDILKEAN EKLKICETQL QTYKKKLEDY NDLKKQIKLQ EERSADYLKQ NLEYEEEAKK
     YAGLKGQVEL YKKKIQDLHG MLDEEMGKTV RAEFEYNQLQ GQLAVVQREK ETLLSERDTL
     REALDELKCG QAVGADGVGH GGPGGNTMSK ELHSNDVCER IERLERENKA LREGQGGQTA
     LSQLLDDANQ RNEKLREQLK SANQKILLLS QHHAEDGTTK SELEMQMKQT LELGEQRSSA
     QQQLDETTQH QLSNLHTKIA NLEAALVVKD QELQAADVRY KKCVEKAKEV IKTLDAHAIS
     EALLMDKVDS ASGTGVDATL TTVGNGGTAA RAPMGQQEEQ LIATAFYRLG MVCHREAVDA
     RLLSGPGQSF LARQRQPAAR KPLNANYAKK