ID   HOOK_DICDI              Reviewed;         734 AA.
AC   Q54IK9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Protein hook homolog;
DE   AltName: Full=DdHk3;
GN   Name=hook; Synonyms=hk3; ORFNames=DDB_G0288691;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Cytoskeletal linker protein involved in tethering membrane
CC       bound organelles to the cytoskeleton. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with microtubules (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- DOMAIN: The large coiled coil domain may mediate homodimerization.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hook family. {ECO:0000305}.
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DR   EMBL; AAFI02000120; EAL63077.1; -; Genomic_DNA.
DR   RefSeq; XP_636577.1; XM_631485.1.
DR   AlphaFoldDB; Q54IK9; -.
DR   SMR; Q54IK9; -.
DR   STRING; 44689.DDB0219928; -.
DR   PaxDb; Q54IK9; -.
DR   EnsemblProtists; EAL63077; EAL63077; DDB_G0288691.
DR   GeneID; 8626750; -.
DR   KEGG; ddi:DDB_G0288691; -.
DR   dictyBase; DDB_G0288691; hook.
DR   eggNOG; ENOG502RSPB; Eukaryota.
DR   HOGENOM; CLU_377875_0_0_1; -.
DR   InParanoid; Q54IK9; -.
DR   OMA; LEFNNHA; -.
DR   PhylomeDB; Q54IK9; -.
DR   PRO; PR:Q54IK9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; ISS:dictyBase.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:dictyBase.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR008636; Hook_C.
DR   InterPro; IPR043936; HOOK_N.
DR   Pfam; PF05622; HOOK; 1.
DR   Pfam; PF19047; HOOK_N; 1.
DR   PROSITE; PS50021; CH; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..734
FT                   /note="Protein hook homolog"
FT                   /id="PRO_0000333270"
FT   DOMAIN          1..113
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REGION          146..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          200..245
FT                   /evidence="ECO:0000255"
FT   COILED          291..700
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   734 AA;  84236 MW;  26E3C44E174648BB CRC64;
     MIETSFIKWI NSFKDLSNSI EDLKELSNGT IFNEICCQIA PKYFDIDSLR KDGLDNWIFR
     EENIKNIVER VDEFYIEEMG LNDQISSINC EEIANENIDE IILLIEAILG MAMESENNEA
     VIENILSLDQ DTQNDLMVVV AKIQQSHQPN TVDNSKSFDK DGSILSQSPS QSNNSISNNN
     NNNNIDSSNI SKSNISSNNN NNNSSNNNKE EILNLQNEIE KLKREKQEIQ NDLDESNIQL
     SNVTMDRDRI TIDKQKTEEV CSSLHESIIG LQKQLDETMA QTTTMNALND ETYKTEINDL
     HMQVESKEKQ LSELKKKVDE ANRLANENRS LRDEIDILRE KAANAEATEE KLKKHQKKIE
     EIGDLKKKIK ELEDQNDSYI QQTLDLEEQL SKNNTYRTQA DSGKQQISSL KIELAKLELS
     LKSIKEDRDK LSESLNTVEL ERDSLQSQVT NLRNTIDNQQ QEYETKFVDL QSSISLNSGG
     SGGLGDEVID GSTKERIARL ERDNKRLKEV AEKASELENQ LEDANQSKEL LTIQIKQLEE
     QKQQSNNTNN NNNNNNMVDS SEIESLKQQL KEKEKEISTL KRKLEESNLS LDENRKQLVE
     LSQRPTTQSP GDIEKLENYE NLLKENDGLE GRLRAARNII KDLREKHKSY SNQETQLATK
     DEVITKLEGL VKKKTDINED LRKQLEEGRE ESQREINLML SAFLKIGLEM EQVKIQNISS
     SKEPRSFLNK KRAD